Research

  • Key biological mechanism that promotes healthy ageing identified

    A study has identified immune resilience as a key driver of salutogenesis — the active process of promoting health and well-being. By analysing data from 17,500 individuals across various life stages, investigators uncovered the importance of immune resilience involving TCF7, a gene essential for maintaining immune cell regenerative potential, in fostering healthy ageing and longevity. [...]

  • Tracking and predicting ageing with DNA methylation entropy

    Researchers have discovered a new way to measure changes in DNA that can help predict a person’s age using a method that focuses on how random certain chemical tags on DNA become over time. The method focuses on how random certain chemical tags on DNA become over time. The team compared this new measurement, called [...]

  • Supercharged mitochondria spark ageing-related blood disorders

    As we age, blood stem cells, the essential source of new blood cells in the body, can accumulate genetic mutations. These mutations can give the cells a growth advantage, laying the foundation for developing serious health conditions. Now, scientists have not only discovered the mechanism that fuels their unchecked growth but have also found a [...]

  • Eye test could predict postoperative delirium in older patients

    Postoperative delirium is a common and serious complication affecting older surgical patients, often leading to prolonged hospital stays, increased need for long-term care, and a higher likelihood of cognitive decline and dementia. Despite its prevalence, identifying patients at risk of developing postoperative delirium remains a significant challenge. Professor Yuan Shen, from Shanghai Mental Health Center, [...]

  • New system could help reduce unnecessary surgery to prevent strokes

    Researchers at UCL have tested a new scoring system to measure the risk of stroke in patients with narrowed arteries due to atherosclerosis, which could prevent unnecessary surgeries and stents. Atherosclerosis is a condition where the blood vessels become narrowed and hardened due to the buildup of plaque, including in the carotid arteries, which carry [...]

  • Largest ever genome-wide association study uncovers new drug targets for osteoarthritis

    The largest genome-wide association study ever performed on osteoarthritis has found 962 genetic markers associated with the condition, including 513 new ones that were never reported in previous studies. Currently, no treatment exists to target the causes of the osteoarthritis or to reverse or halt the damage the disease does to joints. Medications currently on [...]

  • Ageing triggers inflammation and stress in retinal cells, raising risk of vision loss

    A new research paper has revealed that ageing causes inflammation, oxidative stress, and gene disruption in the retinal pigment epithelium (RPE), a vital layer of cells in the eye, raising the risk of vision loss as we age. These changes may explain why older adults are more vulnerable to age-related eye diseases. The researchers also [...]

  • Radiofrequency technology treatment can clear brain toxins while awake

    A new paper has presented clinical studies that show how treating the brain while it is awake with radiofrequency wave treatment can induce brain cleansing that is normally achieved with sleep. The bioengineered radiofrequency technology has the potential to counter the effects of insomnia and sleep deprivation on brain toxin cleansing, and to reduce the [...]

  • Social isolation linked to poor diet in older women

    A new UBC study finds that persistently isolated older Canadian women are more likely to fall short of recommended fruit and vegetable intake, leading to poorer overall diet quality. Researchers used data from the Canadian Longitudinal Study on Aging (CLSA), which tracked 30,097 adults over six years, to examined how long-term social patterns impacted eating [...]

  • Review reveals anti-ageing effects and mechanisms of ginseng compound

    Ginseng, known as the "king of herbs," has long been valued for its health benefits and contains various bioactive compounds, with ginsenosides being the most prominent. In particular, ginsenosides such as Rg2 and Compound K (CK), have demonstrated promising anti-ageing properties. They prevent collagen degradation, inhibit matrix metalloproteinase-1 (MMP-1) expression, and activate multiple antioxidant and [...]