Research
A new AI tool flags early Alzheimer's, identifying about four in five people who would otherwise be missed by clinicians. Trained on UCLA Health patient records and tuned to work more fairly across Black, Latino and Asian patients who are often underdiagnosed, the system aims to find people earlier, when treatment and lifestyle changes can [...]
Gap is partnering with Spear Bio on Bio-Hermes-002, an Alzheimer's study comparing blood and digital biomarkers across cognitive conditions. The observational platform study compares blood-based and digital biomarkers (measurable signs in blood or behaviour) across a broad range of cognitive conditions, alongside MRI and PET brain scans and diverse racial and ethnic groups, to generate [...]
Scanning ultrasound was safe and well tolerated in a first-in-human Alzheimer’s pilot study contucted in Australia. The pilot split 12 people with Alzheimer’s into groups to test different levels of ultrasound stimulation in the brain. Alzheimer’s is the most common form of dementia and affects more than 480,000 Australians. Without major scientific advances, 6.4 million [...]
BioAge Labs is expanding its lead drug candidate into diabetic macular oedema, with plans to start a phase 1b/2a trial in mid-2026. The clinical-stage biotechnology company will test BGE-102, an oral therapy, in patients with the condition, which is one of the most common causes of vision impairment among people with diabetes. Diabetic macular oedema [...]
The USC Clinical Trial Recruitment Lab will fund four projects testing how AI can strengthen recruitment for Alzheimer's trials. The initiative, dedicated to accelerating and improving Alzheimer's clinical trials, selected the projects from more than 30 applicants to explore digital approaches. Alzheimer's clinical trials are more complex, costlier and take longer than those in other [...]
Scientists have developed a nanoparticle strategy to broaden which disease-causing proteins medicines can target, giving options for dementia and brain cancer. A perspective outlines an approach designed to remove harmful proteins that drive disease. By broadening the proteins that can be treated, the technology could help tackle conditions such as dementia and brain cancer. The [...]
SciNeuro Pharmaceuticals has entered a worldwide licensing and collaboration agreement with Novartis to advance its amyloid beta-targeted antibody programme for Alzheimer's disease. The programme has identified de novo antibody candidates that incorporate what SciNeuro describes as its proprietary blood-brain barrier shuttle technology, designed to help drugs cross the protective barrier around the brain, and which [...]
Shingles vaccination may slow biological ageing in older adults, research suggests. The study examined more than 3,800 people aged 70 and older and found that those who received the vaccine showed slower biological ageing on average than unvaccinated individuals. The study used data from a nationally representative US survey to assess how shingles vaccination related [...]
Sharp rises in blood sugar after meals may raise Alzheimer’s risk, according to genetic analysis of more than 350,000 adults. The findings point to after-meal glucose, rather than overall blood sugar, as a possible factor in long-term brain health. Researchers examined genetic and health data from over 350,000 UK Biobank participants aged 40 to 69, [...]
A recent international study that pooled brain scans and memory tests from thousands of adults has shed new light on how structural brain changes are tied to memory decline as people age. The findings show that the connection between shrinking brain tissue and declining memory is nonlinear, stronger in older adults, and not solely driven [...]
