Research
A newly identified link between brain activity and mitochondrial function could aid the development treatments to arrest cognitive decline. Mitochondria play a pivotal role in meeting the dynamic energy demands of neuronal activity, producing adenosine triphosphate (ATP) primarily via oxidative phosphorylation (OXPHOS). However, in the ageing mammalian brain, mitochondrial metabolism deteriorates, leading to profound effects on neuronal [...]
Significant improvements have been shown in the health of older adults in England when compared to previous generations. Rather than considering health through the presence or absence of disease, the study applied a new approach that examined trends in people’s functioning – their cognitive, locomotor, psychological, and sensory capacities. Using data from the English Longitudinal [...]
For healthy older adults, using antibiotics is not associated with an increased risk of cognitive impairment or dementia, according to a new study. Cognitive impairment is when someone has subtle changes in thinking and memory like forgetting events and losing items more often. Dementia is when thinking and memory problems become more advanced and affect [...]
A £4.4m grant has been awarded for the new CircadiAgeing Research programme that will investigate the role of circadian rhythms in healthy ageing. The CircadiAgeing project will explore how disruptions in circadian rhythms, the natural 24-hour cycles of physiological and behavioural patterns, contribute to ageing and related health issues. Focusing on both the molecular clock and [...]
Anti-CCR5 nanoparticles to treat Alzheimer’s disease are to be developed with support of a major funding boost. Alzheimer's disease and dementia are debilitating diseases affecting over 6.7 million people in the United States and over 55 million people worldwide. The condition is characterised by multiple factors such as amyloid plaque formation, tau protein entanglement, enzyme [...]
A team of researchers are to advance research on an innovative approach to slowing age-related cognitive decline in women with a major funding boost. According to the university, USC will receive the US$3.4m in funding over two years through the Sprint for Women’s Health spark track for early-stage research efforts. Young-Kwon Hong, chief of the [...]
Prostate cancer remains a global health challenge, ranking as the second most commonly diagnosed cancer among men. Although treatments like androgen deprivation therapy have been effective for early-stage prostate cancer, advanced stages, such as castration-resistant prostate cancer, present significant treatment challenges due to resistance to therapies. Current approaches targeting androgen receptor (AR) signalling, such as [...]
Several studies suggested that older people had a somewhat reduced immune response to the mRNA Covid vaccines when compared with younger adults. Researchers have now found some answers on why — while providing proof-of-concept of a new system that can model mRNA vaccine responses in a dish. The model could help expedite efforts to make [...]
Researchers have discovered that young people with sickle cell disease (SCD) exhibit signs of accelerated biological ageing compared to those without the disease. By measuring levels of p16INK4a, a key marker of cellular ageing, the team found significantly higher levels in individuals with SCD. Remarkably, some participants showed biological ageing equivalent to an additional 43 [...]
New research suggests that living in a disadvantaged neighbourhood is associated with higher blood pressure and lower cognitive scores, even among people who do not have an existing diagnosis of mild cognitive impairment. Cognition refers to the mental process of thinking, learning, remembering, being aware of surroundings and using judgment. Mild cognitive impairment is a [...]
