Research
A large clinical food trial will test whether a combination of probiotics and prebiotics (BondiaÒ or SBD111) will help manage bone health in women aged 60 years and above. The first participants have joined the study and the Institute seeks additional women for the 18-month effort. Principal investigator Dr. Shivani Sahni, and her research team [...]
A new study backed by US$5.3m will examine the correlation between walking and mild cognitive impairment (MCI) in the hope of unveiling neural mechanisms underlying the relation between mobility and cognitive decline to enhance early Alzheimer's Disease and Related Dementias (ADRD) risk prediction. The study will begin by screening research participants for MCI, a condition [...]
Researchers have uncovered compounds that boost the activity of Sirtuin-3 (SIRT3) - an important age-regulating enzyme which was previously thought to be impossible to target with drugs. SIRT3 keep our mitochondria - known as the cell's energy factories - working properly. According to researchers, the newly discovered compounds work by making SIRT3 more responsive to [...]
Steam could potentially be harnessed to kill cancer cells in prostate cancer patients, researcher believe. The clinical trial is designed for patients with intermediate-risk prostate cancer, meaning that the tumour is localised in the prostate gland and has not spread to other organs. Some patients with prostate cancer may not need any treatment if the [...]
Researchers have conducted a review into how genetic variations can explain differences in when we have children, the timing of menopause, and how long we live. The review looked male and female genetic discoveries, identifying 159 genetic studies and 37 key genes that are linked to reproductive traits such as age at first childbirth, menopause timing, [...]
Within five to 10 years, one in two older adults will use wearable devices daily to forecast life-threatening risks, predicts new research. Researchers analysed wearable adoption trends in the US over the past decade and uncovered slower uptake among older generations. The study identifies barriers to adoption and suggests that wearable manufacturers can better address [...]
A new study has provided a roadmap for how ageing may alter brain cell genetic activity, revealing that not all cell types in the brain age in the same way. The researchers found that some cells, such as a small group of hormone-controlling cells, may undergo more age-related changes in genetic activity than others. The [...]
Researchers have discovered a surprising link between a chronic gut infection caused by a common virus and the development of Alzheimer’s disease in a subset of people. It is believed most humans are exposed to this virus — called cytomegalovirus or HCMV — during the first few decades of life. Cytomegalovirus is one of nine [...]
According to a recently published study, rates of deaths from heart disease — especially among men — are lower in neighbourhoods with more greenspace. Studying heart disease deaths in Philadelphia from 2008 to 2015, the researchers also found that, contrary to their hypothesis, it was in neighbourhoods with more crime where greater park access and [...]
A successful trial of a drug for memory loss in people with Alzheimer’s disease and schizophrenia brings treatment one step closer. VU319 is the first Vanderbilt end-to-end drug discovery effort, starting from the earliest basic science research through human clinical trials. The effort spanned a high-throughput screening hit-to-candidate selection to completion of a clinical trial. [...]
