Research

Researchers have found that a simple blood test could help predict breast cancer risk in older women in a study that focuses on epigenetic ageing - a process that reflects how fast the body’s cells age based on DNA methylation changes (DNAm). Breast cancer is one of the most common cancers worldwide, with the risk [...]

Researchers have developed a promising technique for treating osteoarthritis using therapeutic blood clots activated by messenger RNA. Osteoarthritis occurs when cartilage in key joints like the knees and hips deteriorates, causing pain and stiffness and impeding mobility. The researchers suggest this new method could one day offer a more effective option than treatments such as [...]

Intensive blood pressure control contributes to a significant reduction of the risk of mild cognitive impairment or dementia, even long after stopping the treatment in adults with hypertension and high cardiovascular risk, a new study has shown. The findings highlight the sustained benefits of aggressive blood pressure management in preventing cognitive decline. The study involved [...]

Antibiotics, antivirals, vaccinations and anti-inflammatory medication are associated with reduced risk of dementia, according to new research that looked at health data from over 130 million individuals. The study identified several drugs already licensed and in use that have the potential to be repurposed to treat dementia. Despite intensive efforts, progress in identifying drugs that [...]

While genomic classifier (GC) tests may influence risk and treatment decisions for patients with localised prostate cancer (PCa), there is a need for better data on their cost-effectiveness, clinical utility, and their impact on racial and ethnic groups, say researchers Prostate cancer is the most common cancer among men, with cases ranging from barely noticeable [...]

Three psychological profiles associated with different patterns of cognitive and brain decline in ageing have been identified in a new study, findings that could lead to the development of personalised prevention strategies. The study, which analysed more than 1,000 middle-aged and older adults, shows that the specific psychological characteristics of each profile may influence the [...]

Researchers have shown that the amount of a protein called CD74 can indicate which people with bowel cancer may respond best to immunotherapy. If integrated into the clinic, testing for this protein could potentially allow hundreds of previously ineligible patients to benefit from this type of treatment. Bowel cancer is the fourth most common cancer [...]

A new study has identified genetic risks for age-related macular degeneration (AMD), a condition which affects about 200 million people worldwide and can result in blindness. For the study, a team of scientists worked with a large biobank of veterans recruited at more than 60 U.S. Department of Veterans Affairs (VA) medical centres across the [...]

Mild cognitive impairment is linked to blood vessel dysfunction in the brain’s temporal lobes, the seat of memory, according to a new study. The findings, seen in people with and without signs of amyloid build up in the brain, suggest that microvascular trouble may be an important, early biomarker for dementia as well as a [...]

A new study has revealed how two proteins interact with water and other matrix components to regulate the mechanical behaviour of bone – findings that could open new doors to understanding bone biology and potentially lead to the development of innovative treatments for bone-related diseases like osteoporosis. The team has uncovered the essential roles of [...]