News
Young-onset dementia research lays groundwork for new prevention strategies

A team of researchers in the UK and Germany has identified a wide range of risk factors for young-onset dementia.
The findings challenge the notion that genetics are the sole cause of the condition and lay the groundwork for new prevention strategies.
The largescale study identified a total of 15 risk factors, which are similar to those for late-onset dementia.
For the first time, the findings indicate that it may be possible to reduce the risk of young-onset dementia by targeting health and lifestyle factors.
Professor David Llewellyn of the University of Exeter said: “This breakthrough study illustrates the crucial role of international collaboration and big data in advancing our understanding of dementia.
“There’s still much to learn in our ongoing mission to prevent, identify, and treat dementia in all its forms in a more targeted way.
“This is the largest and most robust study of its kind ever conducted.
“Excitingly, for the first time it reveals that we may be able to take action to reduce risk of this debilitating condition, through targeting a range of different factors.
Relatively little research has been done on young-onset dementia of which there are around 370,000 new cases globally each year.
The new research followed more than 350,000 participants younger than 65 across the United Kingdom from the UK Biobank study.
The researchers evaluated a broad array of risk factors ranging from genetic predispositions to lifestyle and environmental influences.
The study found that lower formal education, lower socioeconomic status, genetic variation, lifestyle factors such as alcohol use disorder and social isolation, and health issues including vitamin D deficiency, depression, stroke, hearing impairment and heart disease significantly elevate risk of young-onset dementia
Sebastian Köhler, Professor of Neuroepidemiology at Maastricht University, said: “We already knew from research on people who develop dementia at older age that there are a series of modifiable risk factors.
“In addition to physical factors, mental health also plays an important role, including avoiding chronic stress, loneliness and depression.
“The fact that this is also evident in young-onset dementia came as a surprise to me, and it may offer opportunities to reduce risk in this group too.”
The research was supported by Alzheimer’s Research UK, The Alan Turing Institute/Engineering and Physical Sciences Research Council, Alzheimer Nederland, Gieskes Strijbis Fonds, the Medical Research Council, the National Institute for Health and Care Research (NIHR) Applied Research Collaboration South West Peninsula (PenARC), the National Health and Medical Research Council, the National Institute on Aging, and Alzheimer Netherlands.
Dr Janice Ranson, Senior Research Fellow at the University of Exeter, said: “Our research breaks new ground in identifying that the risk of young-onset dementia can be reduced.
“We think this could herald a new era in interventions to reduce new cases of this condition.”
Dr Leah Mursaleen, Head of Clinical Research at Alzheimer’s Research UK, added: “This pioneering study shines important and much-needed light on factors that can influence the risk of young-onset dementia.
“This starts to fill in an important gap in our knowledge. It will be important to build on these findings in broader studies.”
News
Older male athletes may face increased risk of serious heart problems during exercise

Veteran male athletes may face higher heart risk during exercise if they have existing heart scarring, new research suggests.
The study found that male endurance athletes aged over 50 were more likely to experience abnormal heart rhythms during training if scarring was present.
Nine in 10 sudden cardiac deaths during sport occur in older male athletes.
Researchers at the University of Leeds tracked 106 healthy male endurance athletes aged over 50 who had been doing more than 10 hours of running or cycling weekly for at least 15 years.
They matched training data from wearables with implantable loop recorders to align heart rhythms with activity.
Over two years, about one in four participants experienced ventricular tachycardia, a fast, abnormal rhythm arising from the heart’s lower chambers, during or just after exercising.
Three quarters of those who had these episodes had heart scarring. There were three sustained episodes during exercise, all in athletes with scarring.
Scarring may be caused by heart attacks, disease or cumulative exertion from years of high-intensity exercise.
Dr Wasim Javed, research fellow at the University of Leeds and lead author, said: “Our study shows that exercise was only associated with a risk of developing abnormal heart rhythms in those who were already high risk due to heart scarring.
“Athletes who developed abnormal heart rhythms were not exercising more or harder than athletes without abnormal heart rhythms.
“This suggests that exercise itself is not the cause, but could act as a trigger for dangerous heart rhythms in those athletes already with an underlying heart issue.”
“Exercise is safe and has immense benefits – but athletes in this group should have regular health checks to make sure they stay healthy.”
The researchers said their findings support the use of wearable technology for athletes who want to monitor their heart rate for unusual activity.
News
Childhood exposure to indoor air pollution linked to long term brain harms

Childhood exposure to indoor air pollution may have long-term effects on brain health, with cognitive impairment appearing decades later, new research suggests.
The study analysed data from over 7,000 Chinese adults aged 45 and above using machine learning techniques.
Nearly 30 per cent of the global population, roughly 2.4bn people, still cook without clean fuels such as gas or electricity, instead using solid fuels like coal, wood and plant waste.
Researchers at the University of Helsinki found that individuals exposed as children to indoor air pollution from solid fuels performed significantly worse on cognitive tests in adulthood, particularly in episodic memory and overall mental health.
The study identified two main pathways through which childhood exposure may contribute to poorer cognitive performance: biological, including being overweight and limitations in daily activities; and socioeconomic, with exposure associated with lower education and income levels.
Men, smokers and regular alcohol users were particularly vulnerable to the detrimental effects.
Xu Zong, the study’s author, said: “Our study emphasises that early exposure to air pollution affects later cognitive health through both biological and social pathways.
“That is why public health efforts should combine clean energy initiatives with preventive strategies that support lifelong health and positive behaviours.
“Switching to cleaner fuels, such as gas or electricity, is not merely an environmental or respiratory health measure.
“It is also an investment in long-term cognitive wellbeing that could safeguard brain health for future generations.”
Technology
SimpleC launches AI companion for dementia carers

SimpleC has launched Wellby, an AI companion for unpaid dementia carers, offering round-the-clock emotional support and practical guidance.
Announced at CES in Las Vegas, Wellby is designed for caregivers of people with Alzheimer’s disease and related dementias.
Some 63 million people in the US provide unpaid care to older adults, including 12 million specifically caring for those with dementia. SimpleC says many face emotional strain, uncertainty and limited timely guidance.
Unlike general-purpose AI tools, Wellby is built for caregiving support, delivering personalised, real-time assistance through natural conversation.
Kevin Henze, chief executive of SimpleC, said: “This launch reinforces our belief that technology should support caregivers with both intelligence and compassion.
“As a privately owned, mission-driven company, we’re able to prioritise affordability, accessibility, and long-term caregiver impact. Wellby represents technology with soul—AI designed to truly walk alongside caregivers.”
Future releases will integrate the companion into SimpleC’s Connected Care Platform and extend it to serve older adults ageing in place.
Jun Ying, chief product officer, said: “By integrating AI across our platform, we’re creating a connected ecosystem where caregivers and care recipients can access multiple services—support, monitoring, guidance, and coordination—through a single, trusted SimpleC experience.”
Wellness4 weeks agoCommonly-prescribed drugs liked to 50% increased risk of dementia
News4 weeks agoVaccine raises hope for million living with knee osteoarthritis
Insights4 weeks agoStudy reveals habits that could lower brain age by eight years
Insights4 weeks agoLoss of confidence in midlife linked to dementia
News4 weeks agoConcurrent frailty and depression likely boost dementia risk in older people, study finds
News4 weeks agoSanofi and ADEL sign US$1.04bn Alzheimer’s deal
Wellness4 weeks agoYellow wristbands launched to help locate people with dementia
Insights4 weeks agoSitting by window improves blood sugar control in diabetes patients – study



















