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Prostate cancer remains a global health challenge, ranking as the second most commonly diagnosed cancer among men. Although treatments like androgen deprivation therapy have been effective for early-stage prostate cancer, advanced stages, such as castration-resistant prostate cancer, present significant treatment challenges due to resistance to therapies. Current approaches targeting androgen receptor (AR) signalling, such as [...]
A new review has explored how genetic variations can explain differences in reproductive health and longevity. The study provides the most comprehensive review of male and female genetic discoveries of reproductive traits to date, and provides new insights into how our DNA affects when we have children, the timing of menopause, and even how that [...]
Several studies suggested that older people had a somewhat reduced immune response to the mRNA Covid vaccines when compared with younger adults. Researchers have now found some answers on why — while providing proof-of-concept of a new system that can model mRNA vaccine responses in a dish. The model could help expedite efforts to make [...]
Shore Capital Partners has launched Agentis Longevity, a new, innovative platform dedicated to advancing comprehensive longevity healthcare. Based in Nashville, USA, Agentis aims to redefine healthy ageing by delivering a suite of services designed to extend health span and address age-related conditions. Agentis will focus on delivering comprehensive care to its patients, including hormone optimisation [...]
Researchers have discovered that young people with sickle cell disease (SCD) exhibit signs of accelerated biological ageing compared to those without the disease. By measuring levels of p16INK4a, a key marker of cellular ageing, the team found significantly higher levels in individuals with SCD. Remarkably, some participants showed biological ageing equivalent to an additional 43 [...]
By Bethan Halliwell, partner and MedTech sector specialist at European IP firm, Withers & Rogers. From chatbots to combat loneliness to tracking systems that can detect subtle changes in the habits and behaviours of vulnerable people in their own homes, AI-based technologies have enormous potential to protect the health and wellbeing of elderly people. With [...]
Cigarette smoking from childhood into early adulthood is associated with an increased risk of premature cardiac injury, new research has found. This early damage to the structure and function of the heart can also significantly increase the chance of future cardiovascular (CVD) mortality in mid-life. Andrew Agbaje, MD, MPH, PhD is lead and senior author [...]
New research suggests that a person’s biological age, which can be higher than his or her chronological age – a concept called accelerated ageing – may predict who’s at risk for developing colon polyps, a known risk factor for colorectal cancer. The findings link accelerated ageing to increased early colorectal cancer risk and indicate that [...]
Delirium and cognitive decline are common complications of anaesthesia and surgery in older adults. Evidence-based recommendations on strategies to reduce the risk of postoperative neurocognitive disorders have now been presented in a new practice advisory. Many older adults develop delirium after surgery, with symptoms such as confusion, lethargy, or agitation. Although most patients recover, delirium [...]
Higher cardiorespiratory fitness in older age is linked to the preservation of several core aspects of cognitive ability that are vulnerable to age-related decline, finds new research. This association holds true irrespective of key risk factors for cognitive decline: age and carriage of the high risk APOE4 gene, the findings show. Cardiorespiratory fitness is a [...]
