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A newly identified link between brain activity and mitochondrial function could aid the development treatments to arrest cognitive decline. Mitochondria play a pivotal role in meeting the dynamic energy demands of neuronal activity, producing adenosine triphosphate (ATP) primarily via oxidative phosphorylation (OXPHOS). However, in the ageing mammalian brain, mitochondrial metabolism deteriorates, leading to profound effects on neuronal [...]
Significant improvements have been shown in the health of older adults in England when compared to previous generations. Rather than considering health through the presence or absence of disease, the study applied a new approach that examined trends in people’s functioning – their cognitive, locomotor, psychological, and sensory capacities. Using data from the English Longitudinal [...]
A team of researchers has discovered a surprising link between a chronic gut infection caused by a common virus and the development of Alzheimer’s disease in a subset of people. The finding could lead to new ways to treat or prevent the condition. It is believed most humans are exposed to cytomegalovirus or HCMV — [...]
AI-based 'ageing clocks' could help to predict health outcomes and lifespan, researchers say. The researchers trained and tested 17 machine learning algorithms using data on markers in the blood from over 225,000 UK Biobank participants, aged 40 to 69 years when they were recruited. They investigated how well different metabolomic ageing clocks predict lifespan and [...]
For healthy older adults, using antibiotics is not associated with an increased risk of cognitive impairment or dementia, according to a new study. Cognitive impairment is when someone has subtle changes in thinking and memory like forgetting events and losing items more often. Dementia is when thinking and memory problems become more advanced and affect [...]
Women born in the most sexist U.S. states experience faster memory decline in later years compared to women born in the least sexist states, according to a new study. The difference between being born in the most versus the least sexist state was equivalent to nine years of cognitive ageing. The study is one of [...]
A £4.4m grant has been awarded for the new CircadiAgeing Research programme that will investigate the role of circadian rhythms in healthy ageing. The CircadiAgeing project will explore how disruptions in circadian rhythms, the natural 24-hour cycles of physiological and behavioural patterns, contribute to ageing and related health issues. Focusing on both the molecular clock and [...]
Anti-CCR5 nanoparticles to treat Alzheimer’s disease are to be developed with support of a major funding boost. Alzheimer's disease and dementia are debilitating diseases affecting over 6.7 million people in the United States and over 55 million people worldwide. The condition is characterised by multiple factors such as amyloid plaque formation, tau protein entanglement, enzyme [...]
A team of researchers are to advance research on an innovative approach to slowing age-related cognitive decline in women with a major funding boost. According to the university, USC will receive the US$3.4m in funding over two years through the Sprint for Women’s Health spark track for early-stage research efforts. Young-Kwon Hong, chief of the [...]
when you relax, whether you reach for the TV controller, or a favourite book, your choice could have implications for your long-term brain health, say researchers. Assessing the 24-hour activity patterns of 397 older adults over the age of 60, researchers found that the context or type of activity that you engage in, matters when [...]
