Research
The engineered protein is activated by the drug rapamycin, which is known to increase life expectancy in preclinical models. Scientists have genetically modified a brain molecule called LIMK1 to boost memory. The research team added a "molecular switch" to the protein which can be activated by administering a drug, rapamycin, known for its several anti-ageing [...]
Fasting interventions, which involve alternating periods of fasting and refeeding, are generally thought to improve health. But these interventions don’t work as well in old animals, according to a study on killfish. By studying the short-lived killifish, researchers at the Max Planck Institute for Biology of Ageing in Cologne have shown that older fish deviate [...]
An international team of researchers has developed a handheld, non-invasive device that can detect biomarkers for Alzheimer’s and Parkinson’s Diseases. The team tested the device on in vitro samples from patients and showed that it is as accurate as current state-of-the-art methods. Ultimately, researchers plan to test saliva and urine samples with the biosensor. The [...]
New research shows that frailty in older adults is linked to increased rates of death and major morbidity following surgery. A new study from researchers at Wake Forest University School of Medicine shows that frailty is associated with higher rates of death and major morbidity after surgery. “Frailty refers to a lack of functional or [...]
A John Hopkins study reveals how timings of orthostatic hypotension impacted the risk of falls among older adults. A new study has brought critical insights into the assessment of orthostatic hypotension, a drop in blood pressure commonly found among older adults when transitioning from a sitting or lying position to a standing position that can [...]
People who have a higher biological age than their chronological age have a significantly increased risk of stroke and dementia, especially vascular dementia. These are the results of a study from Karolinska Institutet in Sweden published in the Journal of Neurology, Neurosurgery and Psychiatry. The study, which was led by Sara Hägg, associate professor, and [...]
Biotech company BioAge Labs has announced plans to initiate a Phase 2 trial of an orally administered treatment for obesity. The Phase 2 trial will examine the efficacy of BioAge Labs' oral apelin receptor agonist BGE-105 (azelaprag) co-administered with the GLP-1/GIP receptor agonist tirzepatide for the treatment of obesity. The trial is expected to start [...]
A recent study has harnessed a plasma fraction derived from young pigs to reduce the biological age of elderly rats, potentially opening up possibilities for rejuvenation in humans. Efforts to employ youthful blood to rejuvenate ageing organisms have been explored for centuries, but only in recent times has this concept gained scientific validation. A new [...]
Scientists have found success in treating a ‘neglected’ inflammatory condition, polymyalgia rheumatica, with a drug that could provide an alternative to steroids for patients. The study, carried out by Anglia Ruskin University and published in the New England Journal of Medicine, describes a successful trial of sarilumab. The drug, which in the UK is approved [...]
Older people who have higher levels of triglycerides, a type of fat, may have a lower risk of dementia and a slower cognitive decline over time compared to people who have lower levels, according to new research. While a link was found, it does not prove that higher levels of triglycerides prevent dementia, the study, [...]
