Research
A new animal study has found a way to restore the brain's waste-clearing process in mice, offering a potential treatment strategy for neurological disorders where the brain struggles to clear out harmful waste such as Alzheimer’s and Parkinson’s. Ageing is a key risk factor for diseases such as Alzheimer’s and Parkinson’s because, as we age, [...]
In a new animal study, researchers have demonstrated how a treatment could lengthen both life span and vigour all the way until death. The study describes how a group of mice lived 9% longer when they received monthly treatments, or about 79 extra days of life. Equally, the study found that the mice demonstrated that [...]
Older age, female sex, irregular heart rhythms, and daily activity levels can help to predict how much Alzheimer’s Disease patients’ cognitive function will decline, according to research. Researchers set out to understand which patient characteristics might best predict cognitive decline in Alzheimer's, following an initial cohort of 500 Austrian patients with probable and possible Alzheimer’s Disease [...]
A relatively new type of degenerative brain disease which was recognised a decade ago is affecting as many as one in two individuals over 85, research suggests. Limbic-predominant age-related TDP-43 encephalopathy (LATE), was first recognised around 10 years ago, and remains relatively unknown. In the disease, the TDP-43 protein accumulates particularly in the limbic brain [...]
New light has been shed on the mechanisms behind memory updating and how those mechanisms can go awry with age. A team of US researchers has identified an enzyme that contributes to age-related impairments in memory updating. When blocked, older mice were better able to incorporate new information and performed similarly to their younger counterparts. [...]
New findings from exploratory analysis of Amylyx Pharmaceuticals' PEGASUS trial provide preliminary evidence that AMX0035 engages multiple pathological pathways related to neurodegeneration, including tau, resulting in consistent changes in Alzheimer’s Disease and neurodegeneration cerebrospinal fluid (CSF) biomarkers. The researchers suggest that AMX0035 - odium phenylbutyrate [PB] and taurursodiol [TURSO] - engages important pathways implicated in [...]
Biotech company Coya Therapeutics has provided an update on its pioneering work to slow the progression of Alzheimer's and other neurodegenerative conditions. Coya Therapeutics has provided an update on a number of recent developments including confirmation that it has received $5.0 million strategic investment by the Alzheimer’s Drug Discovery Foundation (ADDF). The funds aim to help [...]
A team of researchers from the LKS Faculty of Medicine, the University of Hong Kong (HKUMed) has developed a novel cinnamaldehyde-based prodrug nanomedicine for rheumatoid arthritis by utilising cinnamaldehyde, a common food additive, as an anti-inflammatory agent. The novel prodrug forms nanoparticles that deliver the therapeutic agents precisely to the inflamed sites, offering a solution [...]
In an analysis of 30 cancer types among men, investigators have uncovered substantial disparities in cancer cases and deaths by age and countries’ economic status. These disparities are projected to widen by 2050, according to a study based on data from the Global Cancer Observatory. Men face higher rates of cancer and cancer-related deaths than [...]
Those with higher heart pressure estimated by Magnetic Resonance Imaging (MRI) were five times more likely to develop heart failure according to New research looking at more than 39,000 UK biobank participants. MRI scans could replace invasive heart tests, as new research shows they can reliably estimate pressures inside the heart to predict if a [...]
