Research
A new mechanism that is crucial for the initiation of autophagy, a self-degradation process cells use to eliminate unneeded or damaged components, has been identified. In recent years, autophagy has been recognised for its roles in ageing and lifespan regulation. During autophagy, intracellular molecules and structures are sequestered within a membrane-bound structure known as an [...]
A protein called STING, previously shown to control a pathway that contributes to antiviral signaling, also plays an important role in cellular stress clearance and cell survival, a study shows. “It was quite surprising that STING has a protective function for cells to reduce stress and damage in addition to its well-known role in inflammation,” [...]
LinkGevity, an AI-driven drug discovery company focused on longevity and age-related disease, has won a Women TechEU grant. Women TechEU is a project funded through Horizon Europe, the EU's flagship research and innovation funding programme. The award will support LinkGevity’s work in tackling complex, age-related diseases through a new approach to drug discovery. The company [...]
Researchers say it’s not just a normal part of ageing
Results from a large clinical trial show that treatment with an immunotherapy drug may nearly double the length of time people with high-risk, muscle-invasive bladder cancer are cancer-free following surgical removal of the bladder. Researchers found that postsurgical treatment with pembrolizumab (Keytruda), which is approved by the Food and Drug Administration (FDA) for treating at [...]
A new Northwestern Medicine study in mice has discovered a novel way to lengthen the “healthspan” of ovaries — improving maintenance of the ovaries and preventing key age-related changes in ovarian function. A woman’s ovaries are like a factory where eggs grow and produce hormones that regulate everything from menstruation and pregnancy to bone density [...]
Researchers have developed a gel inspired by cow slime for patients suffering from disc herniation. By adding the mucin gel immediately after surgery, it is possible to create a protective barrier around the discs to prevent the immune system from attacking their nucleus pulposus - keeping the discs intact and reducing the risk of further [...]
Nanoscope Therapeutics has announced the expected advancement of MCO-010 for the treatment of Stargardt Macular Degeneration (SMD) to a Phase 3 registrational trial following a productive end-of-Phase 2 (EOP2) meeting with the U.S. Food and Drug Administration (FDA). Nanoscope Therapeutics has said that the FDA provided clear input on the proposed Phase 3 registrational trial [...]
Interim data from the first "dose escalation" part of the mRNA cancer immunotherapy study shows promise in patients with advanced solid cancers, researchers say. The investigational mRNA cancer immunotherapy is targeted for patients with lung cancer, melanoma and other solid tumours. Nineteen patients with advanced stage cancers received between one and nine doses of the [...]
Older people with mild cognitive impairment who engage in high levels of activities such as word games and hobbies have better memory, attention and processing speed than those who do not. That is according to a new study based on an analysis of data on almost 6,000 people by the Texas A&M University School of Public [...]
