Research
The treatment landscape for patients with prostate cancer, especially individuals with advanced disease, has dramatically changed in recent years. However, aside from drug or hormonal therapies, other targets to treat prostate cancer are still necessary to prolong life and slow the progression of this potentially lethal disease. A new study has now found that inhibition [...]
In science, the most fascinating breakthroughs often come from unexpected places. For Dr. Etienne Sibille, professor at the University of Toronto, and director of the Neurobiology of Depression and Aging program at CAMH, and co-founder and Chief Scientific Officer of Damona Pharmaceuticals, the path to revolutionising mental health treatment began not in a laboratory, but [...]
An international study has found frailty increases a person’s risk of dementia, but early intervention may be the key to prevention. Dr David Ward from the Centre for Health Services Research at the University of Queensland tracked the data of nearly 30,000 participants of four longitudinal studies in the United Kingdom and the United States, [...]
A team of scientists has uncovered the intricate mechanisms by which immunoglobulins influence the aging process, a finding that might reshape our understanding of ageing. The research not only charts a high-precision map of ageing across various organs but also reveals the dual-edged sword of immunoglobulins in systemic ageing. The quest for systemic biomarkers and [...]
When performing knee replacement surgery, also called total knee arthroplasty, doctors traditionally try to align the hip, knee, and ankle in a straight line, forming a neutral alignment, rather than replicating the patient’s original alignment. Now, in an effort to understand which approach is better, researchers from Kyushu University collected convincing evidence in favour of [...]
A new study has found a surprising link between high levels of methylmalonic acid and the weakening of CD8+ T cells, shedding light on potential pathways through which ageing may promote lung cancer progression. Moffitt Cancer Center researchers have found new insights into how metabolic changes associated with aging can impact immune responses against tumours. [...]
A low-sugar diet in utero and in the first two years of life can meaningfully reduce the risk of chronic diseases in adulthood, a new study has found, providing compelling new evidence of the lifelong health effects of early-life sugar consumption. Published in Science, the study finds that children who experienced sugar restrictions during their [...]
Socioeconomic factors such as education, occupation, and wealth influence the likelihood of developing cognitive impairment or dementia in later life and whether a person is likely to recover, finds a new study led by UCL researchers. The research followed 8,442 adults aged 50 and above in England over 10 years from 2008/09 to 2018/19, to [...]
Polypharmacy, commonly defined as taking five or more medications daily, is a significant health care concern impacting over 30 per cent of older adults. It is associated with poor health outcomes like falls, medication interactions, hospitalisations and even death. Older adults are at an increased risk of experiencing polypharmacy if they have multiple chronic conditions. [...]
For the first time, scientists have tracked what happens to stem cells decades after a transplant, lifting the lid on the procedure that has been a medical mystery for over 50 years. A growing body of evidence suggests that stem cell transplants may be affected by ageing process, impacting their ability to renew. Researchers from [...]
