Dementia & cognitive health
The Scottish Medicines Consortium has declined to recommend the Alzheimer's therapy donanemab (Kisunla, Eli Lilly) for early-stage disease in NHS Scotland. The decision affects patients with mild cognitive impairment and mild dementia caused by Alzheimer's disease who are apolipoprotein E epsilon 4 heterozygotes or non-carriers, a genetic marker. The consortium cited uncertainty over clinical relevance [...]
A recent international study that pooled brain scans and memory tests from thousands of adults has shed new light on how structural brain changes are tied to memory decline as people age. The findings show that the connection between shrinking brain tissue and declining memory is nonlinear, stronger in older adults, and not solely driven [...]
Concurrent physical frailty and depression likely boost the risk of dementia in older people, with the interaction of these two factors alone contributing around 17 per cent of the overall risk, suggest the findings of a large international study. Globally, some 57 million people are living with dementia - a figure that is expected to [...]
A new tool can estimate Alzheimer’s risk years before memory and thinking problems emerge, offering personalised risk scores long before symptoms. The research builds on decades of data from one of the world’s most comprehensive population-based studies of brain health. Mayo Clinic researchers developed the prediction model, which found that women have a higher lifetime [...]
Some regions of the brain in people with Alzheimer's reorganise more often while at rest than in people without the disease, and in healthy people this frequent reshuffling sometimes predicts who will develop the condition later, according to a new study. The brain's ability to reorganise various regions is called neural flexibility, says Eleanna Varangis, [...]
Researchers have developed a virtual reality (VR) game that integrates smell - and the game could help prevent cognitive decline. As the global population ages, supporting older adults in maintaining their cognitive and memory functions has become a pressing concern. The United Nations estimates that by the 2070s, there will be over 2.2 billion people [...]
Researchers have found that both low and moderate-high intensity exercise could be valuable tools in the fight against Alzheimer’s. The new research describes the results of the EXERT study (Exercise in Adults with Mild Memory Problems), a multi-site clinical trial of lower or moderate-high intensity exercise in sedentary older adults with amnestic mild cognitive impairment, [...]
