New findings from Pennington Biomedical Research Center show that life span can be increased by making cells less efficient at producing energy.
A new study, published in the journal Aging Cell, showed that BAM15, a compound that makes mitochondria less efficient at producing energy, extended life span in fruit flies, and was associated with less body fat and increased muscle function.
A key focus of these studies was on limiting the ability of mitochondria to make energy. It is generally believed that maximising the efficiency of mitochondria is favourable for health and lifespan across species.
However, in today’s world of excess eating and reduced physical activity, reducing the efficiency of mitochondria may limit fat accumulation by burning calories in a futile cycle.
Research has shown that the life span of insects and mammals can be controlled through experimental manipulation of mitochondrial function, however, the specific role of bioenergetic efficiency to health and longevity has remained largely unknown.
Pennington Biomedical researchers and others have previously demonstrated that restricting bioenergetic efficiency brings with it protection against obesity, Type 2 diabetes, cancer, and other chronic diseases by improving mitochondrial fitness and cellular function.
This current study is the first to show that adding BAM15 to the diet can uncouple mitochondria, extend life span, improve body composition, and protect against age-related decline in motor activity in a fruit fly model of ageing.
The authors state: “In summary, our findings indicate that mitochondrial uncoupling by BAM15 confers life span extension, improves body composition, and protects against age-related decline in locomotor activity in Drosophila (fruit flies). Collectively, these data support an emerging role for restricting bioenergetic efficiency to maintain mitochondrial redox fitness across the life span.”
The authors note that further studies are required in humans to confirm these findings and address effectiveness for improving longevity.
Pennington Biomedical executive director, John Kirwan, co-author of the study, said: “At Pennington Biomedical, we are unique in being able to conduct research in Basic Science, Clinical Research, and Population and Public Health all in one research center.
“This type of research and these findings are a step toward finding new ways to improve a person’s life span and health as we age. At Pennington Biomedical, we are working on ‘solutions from cells to society,’ and the great news for everyone is that breakthrough research is taking place each and every day here at the center.”