By incorporating hormone (steroid) metabolism pathways into an AI-driven model, they have developed a new system to estimate a person’s biological age a measure of how well their body has aged, rather than just counting the years since birth.
We all know someone who seems to defy ageing, people who look younger than their peers despite being the same age. What’s their secret? Scientists may have found a way to quantify this difference.
Using just five drops of blood, this new method analyses 22 key steroids and their interactions to provide a more precise health assessment. The team’s breakthrough study offers a potential step forward in personalised health management, allowing for earlier detection of age-related health risks and tailored interventions.
Ageing isn’t just about the number of years we’ve lived, it’s shaped by genetics, lifestyle, and environmental factors. Traditional methods for estimating biological age rely on broad biomarkers, such as DNA methylation or protein levels, but these approaches often overlook the intricate hormonal networks that regulate the body’s internal balance.
“Our bodies rely on hormones to maintain homeostasis, so we thought, why not use these as key indicators of ageing?” said Dr. Qiuyi Wang, co-first author of the study. To test this idea, the research team focused on steroid hormones, which play a crucial role in metabolism, immune function, and stress response.
The team developed a deep neural network (DNN) model that incorporates steroid metabolism pathways, making it the first AI model to explicitly account for the interactions between different steroid molecules.
Instead of looking at absolute steroid levels which can vary widely between individuals the model examines steroid ratios, providing a more personalised and accurate assessment of biological age.
“Our approach reduces the noise caused by individual steroid level differences and allows the model to focus on meaningful patterns,” said Dr. Zi Wang, co-first and corresponding author of this work. The model was trained on blood samples from hundreds of individuals, revealing that biological age differences tend to widen as people get older, an effect the researchers liken to a river widening as it flows downstream.
One of the study’s most striking findings involves cortisol, a steroid hormone commonly associated with stress. The researchers found that when cortisol levels doubled, biological age increased by approximately 1.5 times. This suggests that chronic stress could accelerate aging at a biochemical level, reinforcing the importance of stress management in maintaining long-term health.
“Stress is often discussed in general terms, but our findings provide concrete evidence that it has a measurable impact on biological ageing,” says Professor Toshifumi Takao, a corresponding author and an expert in analytical chemistry and mass spectrometry.
The researchers believe this AI-powered biological age model could pave the way for more personalized health monitoring. Future applications may include early disease detection, customised wellness programs, and even lifestyle recommendations tailored to slow down aging.