News
Weight loss drug reduces heart attack and stroke risk regardless of weight loss

Semaglutide reduces the risk of heart attack and stroke by 20 per cent, regardless of weight lost, according to the largest study of 17,604 patients.
The drug, the main ingredient in Wegovy, reduced the risk of major adverse cardiac events — including deaths from heart disease, heart attacks or strokes — by 20 per cent, regardless of the weight patients lost.
The findings suggest the drug may have wider benefits beyond weight loss and should not be restricted only to those with the highest body mass index (BMI).
The study, led by researchers at University College London, examined data from 17,604 adults aged 45 and over who were overweight or obese across 41 countries. Half received weekly injections of semaglutide, while the other half were given a placebo.
Previous analysis had already shown semaglutide’s 20 per cent reduction in cardiac events; this follow-up analysis confirmed the benefit remained even when weight loss was minimal.
Even participants who were only mildly overweight — with a BMI of 27, roughly the UK average — saw similar benefits to those with the highest BMI scores.
The benefits were also largely independent of how much weight people lost in the first four months of treatment.
However, a reduction in waist circumference — a measure of abdominal fat — explained about one-third of the observed cardiovascular benefits.
Professor John Deanfield, from UCL’s Institute of Cardiovascular Science, said: “Abdominal fat is more dangerous for our cardiovascular health than overall weight and therefore it is not surprising to see a link between reduction in waist size and cardiovascular benefit.
“However, this still leaves two-thirds of the heart benefits of semaglutide unexplained. These findings reframe what we think this medication is doing.
“It is labelled as a weight-loss jab but its benefits for the heart are not directly related to the amount of weight lost – in fact, it is a drug that directly affects heart disease and other diseases of ageing.”
He added: “This work has implications for how semaglutide is used in clinical practice.
“You don’t have to lose a lot of weight and you don’t need a high BMI to gain cardiovascular benefit. If your aim is to reduce cardiovascular disease, restricting its use to a limited time only and for those with the highest BMIs doesn’t make sense.
“At the same time, the benefits need to be weighed against potential side-effects. Investigations of side-effects become especially important given the broad range of people this medicine and others like it could help.”
The Select trial findings indicate that semaglutide’s cardiovascular effects are likely driven by multiple mechanisms rather than weight loss alone.
While shrinking waistlines contributed to the outcome, most of the heart benefit appears to stem from other biological effects that directly influence cardiovascular pathways.
News
Older male athletes may face increased risk of serious heart problems during exercise

Veteran male athletes may face higher heart risk during exercise if they have existing heart scarring, new research suggests.
The study found that male endurance athletes aged over 50 were more likely to experience abnormal heart rhythms during training if scarring was present.
Nine in 10 sudden cardiac deaths during sport occur in older male athletes.
Researchers at the University of Leeds tracked 106 healthy male endurance athletes aged over 50 who had been doing more than 10 hours of running or cycling weekly for at least 15 years.
They matched training data from wearables with implantable loop recorders to align heart rhythms with activity.
Over two years, about one in four participants experienced ventricular tachycardia, a fast, abnormal rhythm arising from the heart’s lower chambers, during or just after exercising.
Three quarters of those who had these episodes had heart scarring. There were three sustained episodes during exercise, all in athletes with scarring.
Scarring may be caused by heart attacks, disease or cumulative exertion from years of high-intensity exercise.
Dr Wasim Javed, research fellow at the University of Leeds and lead author, said: “Our study shows that exercise was only associated with a risk of developing abnormal heart rhythms in those who were already high risk due to heart scarring.
“Athletes who developed abnormal heart rhythms were not exercising more or harder than athletes without abnormal heart rhythms.
“This suggests that exercise itself is not the cause, but could act as a trigger for dangerous heart rhythms in those athletes already with an underlying heart issue.”
“Exercise is safe and has immense benefits – but athletes in this group should have regular health checks to make sure they stay healthy.”
The researchers said their findings support the use of wearable technology for athletes who want to monitor their heart rate for unusual activity.
News
Childhood exposure to indoor air pollution linked to long term brain harms

Childhood exposure to indoor air pollution may have long-term effects on brain health, with cognitive impairment appearing decades later, new research suggests.
The study analysed data from over 7,000 Chinese adults aged 45 and above using machine learning techniques.
Nearly 30 per cent of the global population, roughly 2.4bn people, still cook without clean fuels such as gas or electricity, instead using solid fuels like coal, wood and plant waste.
Researchers at the University of Helsinki found that individuals exposed as children to indoor air pollution from solid fuels performed significantly worse on cognitive tests in adulthood, particularly in episodic memory and overall mental health.
The study identified two main pathways through which childhood exposure may contribute to poorer cognitive performance: biological, including being overweight and limitations in daily activities; and socioeconomic, with exposure associated with lower education and income levels.
Men, smokers and regular alcohol users were particularly vulnerable to the detrimental effects.
Xu Zong, the study’s author, said: “Our study emphasises that early exposure to air pollution affects later cognitive health through both biological and social pathways.
“That is why public health efforts should combine clean energy initiatives with preventive strategies that support lifelong health and positive behaviours.
“Switching to cleaner fuels, such as gas or electricity, is not merely an environmental or respiratory health measure.
“It is also an investment in long-term cognitive wellbeing that could safeguard brain health for future generations.”
News
SimpleC launches AI companion for dementia carers

SimpleC has launched Wellby, an AI companion for unpaid dementia carers, offering round-the-clock emotional support and practical guidance.
Announced at CES in Las Vegas, Wellby is designed for caregivers of people with Alzheimer’s disease and related dementias.
Some 63 million people in the US provide unpaid care to older adults, including 12 million specifically caring for those with dementia. SimpleC says many face emotional strain, uncertainty and limited timely guidance.
Unlike general-purpose AI tools, Wellby is built for caregiving support, delivering personalised, real-time assistance through natural conversation.
Kevin Henze, chief executive of SimpleC, said: “This launch reinforces our belief that technology should support caregivers with both intelligence and compassion.
“As a privately owned, mission-driven company, we’re able to prioritise affordability, accessibility, and long-term caregiver impact. Wellby represents technology with soul—AI designed to truly walk alongside caregivers.”
Future releases will integrate the companion into SimpleC’s Connected Care Platform and extend it to serve older adults ageing in place.
Jun Ying, chief product officer, said: “By integrating AI across our platform, we’re creating a connected ecosystem where caregivers and care recipients can access multiple services—support, monitoring, guidance, and coordination—through a single, trusted SimpleC experience.”
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