News
Study looks into apathy and Alzheimer’s progression link

Researchers from Indiana University School of Medicine are studying why neuropsychiatric symptoms, such as apathy and irritability, appear in most Alzheimer’s disease patients before the onset of memory loss.
The study, led by Yao-Ying Ma, assistant professor of pharmacology and toxicology, was recently featured in the publication Molecular Psychiatry.
The team of researchers identified a receptor in the brain that leads to a loss of neurons and synaptic structure when used in an Alzheimer’s disease model.
The investigation focused on the nucleus accumbens, a critical brain region processing motivation.
Located in the ventral striatum, this region is not studied much among Alzheimer’s disease researchers, Ma said, it is mainly researched to understand motivational and emotional processes.
Previous studies have shown that the volume of nucleus accumbens, like the cortical and hippocampal regions in the brain, is reduced in adults with Alzheimer’s disease.
Ma, who is relatively new to the field of Alzheimer’s disease research, has a background in drug addiction studies and synaptic communication – the process by which neurons talk to each other in the brain.
Some of the neuropsychiatric symptoms among people who suffer from substance abuse – apathy, mood swings, anxiety – are also found in Alzheimer’s disease patients.
“Even before the onset of cognitive deficits, a significant number of Alzheimer’s patients start showing mood swings, and they have a greater chance to have symptoms of depression,” Ma said.
These neuropsychiatric symptoms, however, tend to occur earlier than memory loss, but no effective treatments are available.
She emphasised that there is an urgent need to understand why those symptoms exist and how they correlate with cognitive deficits.
This study identified synaptic calcium permeable receptors (CP-AMPARs) in the nucleus accumbens in an Alzheimer’s disease model.
The receptor, which is normally absent in that part of the brain, gives permission for calcium to enter the neurons.
This leads to an overload of calcium, which leads to a breakdown of its synaptic structure.
In turn, calcium accumulation triggers a cascade of intracellular changes that can be lethal to the neuron by amplifying calcium overload via a positive feedback mechanism.
This synaptic loss in the brain causes motivation deficits.
Knowing this, Ma said that targeting these receptors in the brain and blocking them could prevent or delay the onset of Alzheimer’s disease associated neuropsychiatric symptoms, and ultimately cognitive deficits.
“If we can postpone the pathological progression in one of the affected areas, like the nucleus accumbens, that may delay pathological changes in other regions.”
Research
Older male athletes may face increased risk of serious heart problems during exercise

Veteran male athletes may face higher heart risk during exercise if they have existing heart scarring, new research suggests.
The study found that male endurance athletes aged over 50 were more likely to experience abnormal heart rhythms during training if scarring was present.
Nine in 10 sudden cardiac deaths during sport occur in older male athletes.
Researchers at the University of Leeds tracked 106 healthy male endurance athletes aged over 50 who had been doing more than 10 hours of running or cycling weekly for at least 15 years.
They matched training data from wearables with implantable loop recorders to align heart rhythms with activity.
Over two years, about one in four participants experienced ventricular tachycardia, a fast, abnormal rhythm arising from the heart’s lower chambers, during or just after exercising.
Three quarters of those who had these episodes had heart scarring. There were three sustained episodes during exercise, all in athletes with scarring.
Scarring may be caused by heart attacks, disease or cumulative exertion from years of high-intensity exercise.
Dr Wasim Javed, research fellow at the University of Leeds and lead author, said: “Our study shows that exercise was only associated with a risk of developing abnormal heart rhythms in those who were already high risk due to heart scarring.
“Athletes who developed abnormal heart rhythms were not exercising more or harder than athletes without abnormal heart rhythms.
“This suggests that exercise itself is not the cause, but could act as a trigger for dangerous heart rhythms in those athletes already with an underlying heart issue.”
“Exercise is safe and has immense benefits – but athletes in this group should have regular health checks to make sure they stay healthy.”
The researchers said their findings support the use of wearable technology for athletes who want to monitor their heart rate for unusual activity.
News
Childhood exposure to indoor air pollution linked to long term brain harms

Childhood exposure to indoor air pollution may have long-term effects on brain health, with cognitive impairment appearing decades later, new research suggests.
The study analysed data from over 7,000 Chinese adults aged 45 and above using machine learning techniques.
Nearly 30 per cent of the global population, roughly 2.4bn people, still cook without clean fuels such as gas or electricity, instead using solid fuels like coal, wood and plant waste.
Researchers at the University of Helsinki found that individuals exposed as children to indoor air pollution from solid fuels performed significantly worse on cognitive tests in adulthood, particularly in episodic memory and overall mental health.
The study identified two main pathways through which childhood exposure may contribute to poorer cognitive performance: biological, including being overweight and limitations in daily activities; and socioeconomic, with exposure associated with lower education and income levels.
Men, smokers and regular alcohol users were particularly vulnerable to the detrimental effects.
Xu Zong, the study’s author, said: “Our study emphasises that early exposure to air pollution affects later cognitive health through both biological and social pathways.
“That is why public health efforts should combine clean energy initiatives with preventive strategies that support lifelong health and positive behaviours.
“Switching to cleaner fuels, such as gas or electricity, is not merely an environmental or respiratory health measure.
“It is also an investment in long-term cognitive wellbeing that could safeguard brain health for future generations.”
News
SimpleC launches AI companion for dementia carers

SimpleC has launched Wellby, an AI companion for unpaid dementia carers, offering round-the-clock emotional support and practical guidance.
Announced at CES in Las Vegas, Wellby is designed for caregivers of people with Alzheimer’s disease and related dementias.
Some 63 million people in the US provide unpaid care to older adults, including 12 million specifically caring for those with dementia. SimpleC says many face emotional strain, uncertainty and limited timely guidance.
Unlike general-purpose AI tools, Wellby is built for caregiving support, delivering personalised, real-time assistance through natural conversation.
Kevin Henze, chief executive of SimpleC, said: “This launch reinforces our belief that technology should support caregivers with both intelligence and compassion.
“As a privately owned, mission-driven company, we’re able to prioritise affordability, accessibility, and long-term caregiver impact. Wellby represents technology with soul—AI designed to truly walk alongside caregivers.”
Future releases will integrate the companion into SimpleC’s Connected Care Platform and extend it to serve older adults ageing in place.
Jun Ying, chief product officer, said: “By integrating AI across our platform, we’re creating a connected ecosystem where caregivers and care recipients can access multiple services—support, monitoring, guidance, and coordination—through a single, trusted SimpleC experience.”
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