News
Round up: Joint venture to advance Klotho-based therapies, and more

Agetech world explores the latest business and investment developments in the world of ageing and longevity.
Joint venture to advance Klotho-based therapies
Nevada-based Avant Technologies and Singapore-based biotech company Austrianova are entering into a joint venture and license agreement to establish Klothonova – a new company focused on pioneering cell-based therapies utilising encapsulated Klotho-producing cells.
Under the terms of the agreement, Klothonova will leverage Austrianova’s cell encapsulation technology to develop and commercialise treatments targeting Alzheimer’s disease, heart disease, cancer, kidney disease, other age-related conditions and longevity promotion.
Austrianova will contribute its intellectual property and ‘know-how’ to the venture.
Avant will provide capital, along with additional resources, to support Klothonova’s formation and operations.
Klothonova will operate as a 50/50 joint venture, with ownership equally split between Avant and Austrianova.
The company will be focusing on developing innovative treatments through the over expression of the Klotho protein, encapsulated using Austrianova’s technology.
Austrianova’s CEO, Brian Salmons, said: “This joint venture with Avant Technologies allows us to combine our proprietary technologies with Avant’s resources to accelerate the development of Klotho-based therapies.
“We are excited about the potential to improve patient outcomes and promote healthier, longer lives.”
The parties say that Klothonova will prioritise the development of treatments for major indications, with each programme independently managed to ensure focused progress.
Biostate AI launches K-Dense Beta to accelerate biological discovery
Biostate AI has launched K-Dense Beta – a multi-agent AI research system that can compress research cycles from years to days, while eliminating hallucinations in generative AI models.
According to the company, in testing, K-Dense has made a scientific breakthrough in longevity research which will be published in a peer-reviewed journal this year.
The K-Dense system coordinates specialised agents that plan experiments, review literature, design analyses, execute code in secure sandboxes and generate publication-ready reports.
The system eliminates hallucinations by operating like a team of independent scientific reviewers, with agents cross-checking references against external databases, adding feedback loops to improve accuracy, and building full traceability and auditability of every decision and action.
“There is a crisis in science right now, where we have too much data and not enough resources to evaluate it,” said Ashwin Gopinath, co-founder and CTO of Biostate AI.
“We have created an AI scientist that can work 24/7, dramatically accelerating discovery while maintaining rigorous scientific standards.”
With integrated access to resources ranging from standard bioinformatics pipelines, tools like Google’s AlphaFold, curated databases and multiple small and large specialised Large Language Models (LLMs), K-Dense can also modularly connect to any tool available through Model Context Protocol (MCP), a universal protocol that allows AI systems to access and co-ordinate external software.
K-Dense’s capabilities were validated in collaboration with Professor David Sinclair, co-director of the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School.
Tasked with building a transcriptomic ageing clock, K-Dense analysed the ArchS4 dataset of more than 600,000 transcriptomic profiles, selecting 60,000 high-quality samples and strategically focusing on 5,000 genes from over 50,000 available.
The analysis revealed that different sets of RNA transcripts become important predictors at different points in life.
Genes useful in one stage were irrelevant in others, showing that ageing is not a uniform process but a sequence of biological programmes that each require their own predictive model.
“K-Dense enabled us to complete an entire research study in just a few weeks, work that typically requires months or years of expert analysis,” said professor David Sinclair at Harvard Medical School.
“It pointed us to markers and pathways that warrant deeper study and helped us build a unified AI model for predicting biological age.
“Importantly, it also provided a measure of how reliable those predictions are, which is critical for scientific applications and has not been available in prior AI approaches.”
The findings have been submitted for peer review and are available as a bioRxiv preprint.
Biostate AI is now validating K-Dense with design partners, including academic institutions, biotechnology startups and major pharmaceutical companies.
US$6.9M to launch AI-native decentralised science platform
Bio Protocol – a decentralised science (DeSci) platform building AI-native infrastructure for biotechnology – has raised US$6.9m.
The financing will support Bio Protocol’s expansion into a full-stack platform for AI-driven decentralised science, scientific funding and drug discovery.
The platform enables distributed groups of researchers, patients and cryptocurrency users to create and grow AI-driven research networks that automate scientific tasks and monetise biotech discoveries.
By integrating AI with blockchain features for co-ordination, funding and data integrity, the platform enables biotech research to move faster from hypothesis to commercial application.
Paul Kohlhaas, founder and CEO of Bio Protocol said: “Science today is locked in institutional black boxes, cut off from the very researchers who birth it and the communities primed to accelerate it.
“By unifying AI, biotech and crypto in a decentralised platform, researchers and citizen scientists everywhere can collaborate more efficiently and back promising biotech from its earliest stages, compressing drug development from decades to months.”
One of Bio Protocols first ‘BioAgents’ – a decentralised AI agent designed to accelerate and reduce the cost of scientific development while maintaining blockchain-verified knowledge flows. – is Aubrai.
Aubrai launched in late August 2025 in partnership with VitaDAO and leading longevity researcher Dr. Aubrey de Grey. Trained on Dr. de Grey’s lab data and community insights, Aubrai has generated more than US$900,000 in research funding.
Bio says it plans to expand the BioAgent framework globally to more researchers, creating networks of agents that surface hidden connections across biology faster than legacy labs.
Dr. Gilberto Lopes joins longevity company Immorta Bio
Longevity company Immorta Bio has announced the appointment of Gilberto de Lima Lopes Jr., to its strategic advisory board.
Dr. Lopes is globally recognised for leadership in lung cancer and immuno-oncology.
He was principal investigator of KEYNOTE-042, the trial that supported the 2019 FDA first-line approval of pembrolizumab (Keytruda) in PD-L1–positive advanced non-small cell lung cancer (NSCLC), broadening access to checkpoint inhibition for hundreds of thousands of patients worldwide since approval.
Immorta Bio’s lead program, SenoVax, is a senolytic immunotherapy designed to train the immune system to selectively eliminate senescent cells – aged, dysfunctional cells – that accumulate in tumours and their microenvironment, and which are associated with immune evasion and resistance to therapy.
According to the company, in preclinical studies, SenoVax has demonstrated anti-tumour activity across multiple solid tumour models, including lung, breast, glioma, and pancreatic cancers, and synergy with checkpoint inhibitors.
The company is working with the US Food and Drug Administration (FDA) to advance SenoVax into a Phase I/IIa study in advanced NSCLC.
“Joining Immorta Bio is an exciting opportunity to extend the promise of immunotherapy beyond traditional cancer care into longevity and healthy aging,” said Dr. Gilberto Lopes.
“The concept behind SenoVax – targeting senescent cells to enhance anti-tumour immunity – builds on the foundation established by checkpoint inhibitors like pembrolizumab.
“I look forward to helping guide the translation of this innovative science to patients.”
Leadership
Agetech investment & innovation round-up

Long-term gut health and female finance, London likes longevity
New York innovator Salvo Health has secured $8.5m in Series A round as it looks to develop new, long-term, gut-health treatments.
The funding round was led by ManchesterStory, City Light Capital and Threshold Ventures, with additional support from The Artemis Fund, Owl Capital, Impact X Capital Partners, Torch Capital and Felicis Ventures.
Eric Collins, co-founder and general partner of Impact X Capital Partners, a UK-based venture capital firm, said: “The key with Salvo is patient-centred care.
“It’s critical to expand access to food as medicine and behavioural health to improve outcomes and lower, long-term health care costs.
“Salvo does exactly that and has shown 76 per cent of patients report improved symptoms, with five accepted abstracts on outcomes, and a 79 per cent drop in GI-related ER utilisation for its patients.
“We can have better care at lower costs with innovation, in the US, and ultimately in the UK and Europe as well.”
The raise brings Salvo’s total equity funding to US$21.6m. Roughly 60m Americans experience chronic gastrointestinal conditions each year.
Salvo Health is positioning itself in the space between overburdened clinics and patients’ everyday lives.
Female longevity in focus
Xella Health – a women’s precision platform focused on fertility, ageing, and body changes – has raised over US$3.7m in pre-seed funding.
The funds will support product finalisation, partnerships, and a Spring 2026 launch, focused on sex-specific longevity and preventive care.
The round was led by Precursor Ventures, with participation from Capital F, Ulu Ventures, and other funds, as well as, strategic angel investors across healthcare, diagnostics, and consumer technology.
Xella is aiming to propel women’s health beyond symptom-based care and fragmented testing to deliver ‘integrated biological insight, clarity, and foresight’.
The company combines advanced diagnostics, longitudinal data, and personalised clinician-led guidance to help women understand what’s happening in their bodies today – and what lies ahead – across fertility, chronic conditions, hormonal health, early cancer detection, and preventative care.
“Our mission is to give women the answers and care they have always deserved,” said Kelly Lacob, co-founder & CEO of Xella.
“Xella is building the infrastructure to decode female biology – getting to the root cause of conditions that uniquely, differently or disproportionately affect women, many of which suffer from an unacceptably poor standard of care today.”
“Xella is rethinking women’s health from the ground up – starting with the insight women need to make sense of their own biology over time,” said Ashtan Jordan, principal at Precursor Ventures.
Age well in London
Two London boroughs have launched their own initiatives aimed at supporting their ageing resident populations.
Basildon Council has approved a new Ageing Population Strategy to support older residents live healthy, independent and connected lives.
The number of residents aged 65 and over in Basildon is projected to rise steadily over the next decade, reflecting national longevity trends.
The council says its ‘taking a proactive, preventative approach to ensure Basildon remains an inclusive, accessible and sustainable place for residents of all ages’.
The strategy emphasises strong partnership working with health services, voluntary and community organisations, local businesses and residents.
Key commitments include:
- Supporting people to remain independent in their own homes for longer,
- Promoting age-friendly design in town centres and public spaces,
- Strengthening dementia-friendly communities,
- Expanding opportunities for volunteering and employment, and
- Continuing investment in activity centres and community-led initiatives that reduce loneliness.
Cllr Melissa McGeorge, cabinet member for ageing population & health, said: “Our ambition is clear: to make Basildon a place where people can age well, feel valued, and continue to thrive at every stage of later life.
The ‘Life Curve’
Meanwhile the London Borough of Richmond has launched a new self-assessment tool developed by ADL Research and Newcastle University to help boost longevity.
The ‘Life Curve’ tool is designed to support healthy ageing with personalised advice and practical steps on how to stay active and independent.
Councillor Allen, lead member for adult social care, said: “Getting older doesn’t have to mean we stop being independent and there are small steps we can take to help reduce how getting older limits our lives.
“We have tools and services available in the borough to support residents to take these small daily steps to maintain their health and reduce the risk of conditions like heart disease, cancer and dementia.
“A new tool accessible right from your phone or any other online device is ‘Independent Richmond’, which helps you understand where you are on The Life Curve to help stay on track with healthy habits, keeping active and stay independent for longer.”
News
Bryan Johnson launches US$1m longevity programme

Bryan Johnson has launched a US$1m-a-year longevity programme with just three places, offering access to the exact protocol he has followed for five years.
The programme, called “Immortals”, is offered by the former fintech entrepreneur, now a prominent and often controversial figure in longevity.
Johnson’s unconventional methods have included Botox injections in his genitals (Botox relaxes muscles) and transfusions of blood from his teenage son.
There is no evidence these will help him outlive others.
The “Immortals” package includes a dedicated concierge team, 24/7 access to the BryanAI health coach, extensive testing, continuous tracking of millions of biological data points and what Johnson calls the “best skin and hair protocols.
A lower-cost supported tier is available at US$60,000 per year.
Rivals also target the ultra-wealthy: Biograph’s premium membership costs US$15,000 per year, while Fountain Life’s “ultimate longevity programme” is priced at US$21,500 annually.
Despite the higher price, Johnson’s offer is built on exclusivity, with only three spots available.
News
Cognition and Cera expand Alzheimer’s clinical trials access

Cognition Health and Cera have partnered to expand access to Alzheimer’s clinical trials across the UK.
The collaboration links Re:Cognition Health’s specialist brain health clinics and trial expertise with Cera’s 2.5 million monthly home care visits, creating new pathways to identify and support people earlier in their health journey.
By connecting home care with specialist research centres, the partners aim to offer more people the chance to join studies, giving access to advanced assessment and emerging treatments while contributing to future therapies.
Dr Ben Maruthappu MBE, chief executive and founder of Cera, said: “Many older adults are currently ‘invisible’ to the clinical trials research system because they cannot access traditional clinic-centric recruitment.
“By enabling responsible, consented identification and screening within the home, we can bridge the gap between the community and the clinic.
“We are offering the older generation a seat at the table of global drug discovery, ensuring that the path to a cure starts where they are most comfortable—in their own daily lives.”
Re:Cognition Health has contributed to the development of lecanemab (Leqembi) and donanemab (Kisunla) through international trials, introducing disease-modifying approaches that are reshaping early intervention in Alzheimer’s care.
Older adults remain under-represented in research. NIHR data indicate only about 15 per cent of trial participants are 75 or older, despite high multimorbidity in this group. Dementia trial recruitment in the UK also lags other disease areas.
Through this collaboration, individuals who have not yet accessed specialist memory services can be referred earlier for assessment and potential study participation, with access to new-generation therapies where appropriate.
Cera’s technology-enabled home healthcare model, with daily patient contact and consented data capture, allows timely referral of potential participants from familiar settings to Re:Cognition Health clinics.
Together, the organisations will support earlier and more equitable participation by leveraging Cera’s scale and real-time insights. Carers and nurses deliver visits roughly every second on average, enabling early identification of those who may benefit from memory assessment.
Dr Emer MacSweeney, chief executive and founder of Re:Cognition Health, said: “With one in three people expected to develop dementia in their lifetime, it is essential that we create more inclusive and accessible routes into research.
“This collaboration enables us to extend our reach beyond traditional clinic settings and ensure that people who may benefit from early assessment and research participation are supported to do so.
“Clinical trials offer individuals access to the most advanced diagnostics and emerging treatments, alongside expert medical oversight.
“By identifying people earlier and guiding them through every stage of their journey, we can help improve participants’ experience and potential outcomes, while accelerating the development of the next generation of Alzheimer’s therapies.”
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