Connect with us

News

Research finds genetic risk-factor overlap between Alzheimer’s and all-cause and vascular dementias

Published

on

Scientists at The University of Texas Health Science Center at San Antonio (UT Health San Antonio) have reported the largest-ever genome-wide association study of dementia from all causes, revealing an overlap of genetic risks including neurodegeneration, vascular factors and cerebral small-vessel disease.

Genome-wide association studies help scientists identify genes associated with a particular disease or trait by exploring the entire set of DNA, or genome, of a large group of people – in this case, a dataset of 800,597 individuals, with 46,902 and 8,702 cases of all-cause dementia and vascular dementia, respectively.

Bernard Fongang, PhD is with the Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases at UT Health San Antonio.

The researcher said: “Dementia is a multifactorial disease with Alzheimer’s disease and vascular dementia pathologies making the largest contributions – and yet, most genome-wide association studies focus just on Alzheimer’s disease.

“We conducted such a study of all-cause dementia and discovered a substantial genetic overlap with vascular dementia.”

According to the study, Alzheimer’s disease traditionally is considered the most common dementia subtype, followed by vascular dementia.

The two conditions are clinically distinct, however.

Vascular dementia is diagnosed based on the presence of stroke or extensive cerebral vascular disease, with atherosclerosis and arteriolosclerosis considered the underlying pathologies.

But a wealth of evidence from recent years has emphasized a broad role for brain vascular damage as a major mechanism for cognitive impairment.

It now is increasingly recognized that a component of vascular pathology is prominent in all major dementias and acts synergistically with amyloid beta, tau and other neurodegenerative pathologies to affect dementia risk, the study notes.

Because most genome-wide association studies have focused on Alzheimer’s disease, highlighting multiple genetic risk variants, Fongang’s team conducted such a study of all-cause dementia and examined the genetic overlap with vascular dementia.

Its vast dataset drew from individuals comprising the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE), the Alzheimer’s Disease Genetics Consortium (ADGC), the European Alzheimer Disease Biobank (EADB) and the UK Biobank (UKBB), encompassing four different reported ancestries: European (98.5 per cent), African (1.0 per cent), Asian (0.4 per cent) and Hispanics/Latino (0.1 per cent).

Known genetic variants associated with Alzheimer’s disease were replicated for all-cause dementia and vascular dementia.

Functional analysis revealed the overlap of genetic risks of all-cause dementia with neurodegeneration, vascular risk factors such as hypertension and diabetes, and cerebral small vessel disease.

Essentially, known genetic variants for Alzheimer’s disease were identified as risk factors for all-cause dementia and vascular dementia.

“Our findings expand the current knowledge base of dementia genetics by focusing on both all-cause dementia and vascular dementia,” Fongang said.

“We identified several putative genetic variants and biological pathways associated with all-cause dementia and vascular dementia, and added additional support for the involvement of vascular mechanisms in dementia pathogenesis.”

The study concluded that the results should be validated in additional datasets including non-European individuals.

Research

Older male athletes may face increased risk of serious heart problems during exercise

Published

on

Veteran male athletes may face higher heart risk during exercise if they have existing heart scarring, new research suggests.

The study found that male endurance athletes aged over 50 were more likely to experience abnormal heart rhythms during training if scarring was present.

Nine in 10 sudden cardiac deaths during sport occur in older male athletes.

Researchers at the University of Leeds tracked 106 healthy male endurance athletes aged over 50 who had been doing more than 10 hours of running or cycling weekly for at least 15 years.

They matched training data from wearables with implantable loop recorders to align heart rhythms with activity.

Over two years, about one in four participants experienced ventricular tachycardia, a fast, abnormal rhythm arising from the heart’s lower chambers, during or just after exercising.

Three quarters of those who had these episodes had heart scarring. There were three sustained episodes during exercise, all in athletes with scarring.

Scarring may be caused by heart attacks, disease or cumulative exertion from years of high-intensity exercise.

Dr Wasim Javed, research fellow at the University of Leeds and lead author, said: “Our study shows that exercise was only associated with a risk of developing abnormal heart rhythms in those who were already high risk due to heart scarring.

“Athletes who developed abnormal heart rhythms were not exercising more or harder than athletes without abnormal heart rhythms.

“This suggests that exercise itself is not the cause, but could act as a trigger for dangerous heart rhythms in those athletes already with an underlying heart issue.”

“Exercise is safe and has immense benefits – but athletes in this group should have regular health checks to make sure they stay healthy.”

The researchers said their findings support the use of wearable technology for athletes who want to monitor their heart rate for unusual activity.

Continue Reading

News

Childhood exposure to indoor air pollution linked to long term brain harms

Published

on

Childhood exposure to indoor air pollution may have long-term effects on brain health, with cognitive impairment appearing decades later, new research suggests.

The study analysed data from over 7,000 Chinese adults aged 45 and above using machine learning techniques.

Nearly 30 per cent of the global population, roughly 2.4bn people, still cook without clean fuels such as gas or electricity, instead using solid fuels like coal, wood and plant waste.

Researchers at the University of Helsinki found that individuals exposed as children to indoor air pollution from solid fuels performed significantly worse on cognitive tests in adulthood, particularly in episodic memory and overall mental health.

The study identified two main pathways through which childhood exposure may contribute to poorer cognitive performance: biological, including being overweight and limitations in daily activities; and socioeconomic, with exposure associated with lower education and income levels.

Men, smokers and regular alcohol users were particularly vulnerable to the detrimental effects.

Xu Zong, the study’s author, said: “Our study emphasises that early exposure to air pollution affects later cognitive health through both biological and social pathways.

“That is why public health efforts should combine clean energy initiatives with preventive strategies that support lifelong health and positive behaviours.

“Switching to cleaner fuels, such as gas or electricity, is not merely an environmental or respiratory health measure.

“It is also an investment in long-term cognitive wellbeing that could safeguard brain health for future generations.”

Continue Reading

News

SimpleC launches AI companion for dementia carers

Published

on

SimpleC has launched Wellby, an AI companion for unpaid dementia carers, offering round-the-clock emotional support and practical guidance.

Announced at CES in Las Vegas, Wellby is designed for caregivers of people with Alzheimer’s disease and related dementias.

Some 63 million people in the US provide unpaid care to older adults, including 12 million specifically caring for those with dementia. SimpleC says many face emotional strain, uncertainty and limited timely guidance.

Unlike general-purpose AI tools, Wellby is built for caregiving support, delivering personalised, real-time assistance through natural conversation.

Kevin Henze, chief executive of SimpleC, said: “This launch reinforces our belief that technology should support caregivers with both intelligence and compassion.

“As a privately owned, mission-driven company, we’re able to prioritise affordability, accessibility, and long-term caregiver impact. Wellby represents technology with soul—AI designed to truly walk alongside caregivers.”

Future releases will integrate the companion into SimpleC’s Connected Care Platform and extend it to serve older adults ageing in place.

Jun Ying, chief product officer, said: “By integrating AI across our platform, we’re creating a connected ecosystem where caregivers and care recipients can access multiple services—support, monitoring, guidance, and coordination—through a single, trusted SimpleC experience.”

Continue Reading

Trending

Agetech World