News
Promising ‘first’ in Alzheimer’s drug development

An international team of researchers has made a promising breakthrough in the development of drugs to treat Alzheimer’s Disease.
For the first time, scientists have developed a drug that works on both major aggregation-promoting ‘hotspots’ of the Tau protein – addressing a critical gap in current treatments.
The drug, a peptide inhibitor called RI-AG03, was effective at preventing the build-up of Tau proteins – a key driver of neurodegeneration – in both lab and fruit fly studies.
The research was undertaken by the University of Southampton in collaboration with Lancaster University, Nottingham Trent University, Tokyo Metropolitan Institute of Medical Science and UT Southwestern Medical Centre.
Dr Anthony Aggidis is lead author of the paper, Visiting Researcher at the University of Southampton and former Postdoctoral Research Associate at Lancaster University.
He said: “Our research represents an important step toward creating treatments that can prevent the progression of diseases like Alzheimer’s disease.
“By targeting both of the key areas on the Tau protein, this unique approach could help address the growing impact of dementia on society, providing a much-needed new option for treating these devastating diseases.”
Tau proteins play a crucial role in maintaining the structure and function of neurons (brain cells).
But in Alzheimer’s disease, these proteins malfunction, clumping together to form long, twisting fibrils.
As the fibrils accumulate, they create what are called neurofibrillary tangles – masses of twisted Tau proteins that clog the neurons, preventing them from getting the nutrients and signals they need to survive.
As more neurons die, memory, thinking, and behaviour become increasingly impaired, leading to the cognitive decline seen in Alzheimer’s.
There are two specific ‘hotspots’ of the Tau protein where this clumping tends to happen.
While current treatments target one or the other of these hotspots, RI-AG03 uniquely targets and blocks both.
The peptide-based approach is also more targeted than current treatments, potentially making it safer, with fewer side effects.
The paper describes how RI-AG03 was first developed by Dr Aggidis, in the laboratory of the late Prof David Allsop, using computational biology at Lancaster University, where it was tested in lab dishes.
To test its effectiveness in cells within a living organism, researchers at the University of Southampton then gave the drug to fruit flies that had pathogenic Tau.
These fruit fly models of Alzheimer’s Disease were generated by Dr Shreyasi Chatterjee who is a Senior Lecturer at Nottingham Trent University.
The researchers found the drug suppressed neurodegeneration and extended the lives of the flies by around two weeks – a significant extension considering the life span of the insects.
To understand what was happening, Southampton’s scientists looked deep into the brains of the fruit flies.
Prof Mudher said: “When we didn’t feed the flies with the peptide inhibitor, they had lots of the pathogenic fibrils, which group together to make up a tangle. But when we fed them with the drug, the pathogenic fibrils decreased significantly in quantity.”
“The higher the dosage given, the greater the improvement we saw in the fruit fly’s lifespan.”
To make sure this wasn’t unique to fruit flies, researchers at UT Southwestern Medical Centre tested the drug in a biosensor cell – a type of living human cell line that is engineered to detect pathogenic tau fibril formation.
Here too, they found the drug successfully penetrated the cells and reduced the aggregation of Tau proteins.
The team believe their work will have a significant impact on drug discovery efforts in the field of neurodegenerative diseases and now plans to test RI-AG03 in rodents, before proceeding to clinical trials.
The research was funded by the Alzheimer’s Society.
Dr Richard Oakley, Associate Director of Research and Innovation, said: “Dementia is the UK’s biggest killer, and it applies enormous cost and pressure to our healthcare system which is why we’re committed to funding world leading studies like this one.
“This research is taking promising steps towards a new one-of-a-kind therapy which targets Tau, a damaging protein in the brains of people living with Alzheimer’s, preventing it from clumping together.
“This drug has the potential to be more targeted than others currently being studied, and we hope it will result in fewer toxic side effects.
“It’s important to note that the study is in its early stages, so we don’t yet know if it will work or be safe for humans, but it’s an exciting development and we look forward to seeing where it leads.
“Research will beat dementia, but we need to make it a reality sooner through more funding, more partnerships, and more people taking part in dementia research.
Image: University of Southampton
News
Agetech investment & innovation round-up

Long-term gut health and female finance, London likes longevity
New York innovator Salvo Health has secured $8.5m in Series A round as it looks to develop new, long-term, gut-health treatments.
The funding round was led by ManchesterStory, City Light Capital and Threshold Ventures, with additional support from The Artemis Fund, Owl Capital, Impact X Capital Partners, Torch Capital and Felicis Ventures.
Eric Collins, co-founder and general partner of Impact X Capital Partners, a UK-based venture capital firm, said: “The key with Salvo is patient-centred care.
“It’s critical to expand access to food as medicine and behavioural health to improve outcomes and lower, long-term health care costs.
“Salvo does exactly that and has shown 76 per cent of patients report improved symptoms, with five accepted abstracts on outcomes, and a 79 per cent drop in GI-related ER utilisation for its patients.
“We can have better care at lower costs with innovation, in the US, and ultimately in the UK and Europe as well.”
The raise brings Salvo’s total equity funding to US$21.6m. Roughly 60m Americans experience chronic gastrointestinal conditions each year.
Salvo Health is positioning itself in the space between overburdened clinics and patients’ everyday lives.
Female longevity in focus
Xella Health – a women’s precision platform focused on fertility, ageing, and body changes – has raised over US$3.7m in pre-seed funding.
The funds will support product finalisation, partnerships, and a Spring 2026 launch, focused on sex-specific longevity and preventive care.
The round was led by Precursor Ventures, with participation from Capital F, Ulu Ventures, and other funds, as well as, strategic angel investors across healthcare, diagnostics, and consumer technology.
Xella is aiming to propel women’s health beyond symptom-based care and fragmented testing to deliver ‘integrated biological insight, clarity, and foresight’.
The company combines advanced diagnostics, longitudinal data, and personalised clinician-led guidance to help women understand what’s happening in their bodies today – and what lies ahead – across fertility, chronic conditions, hormonal health, early cancer detection, and preventative care.
“Our mission is to give women the answers and care they have always deserved,” said Kelly Lacob, co-founder & CEO of Xella.
“Xella is building the infrastructure to decode female biology – getting to the root cause of conditions that uniquely, differently or disproportionately affect women, many of which suffer from an unacceptably poor standard of care today.”
“Xella is rethinking women’s health from the ground up – starting with the insight women need to make sense of their own biology over time,” said Ashtan Jordan, principal at Precursor Ventures.
Age well in London
Two London boroughs have launched their own initiatives aimed at supporting their ageing resident populations.
Basildon Council has approved a new Ageing Population Strategy to support older residents live healthy, independent and connected lives.
The number of residents aged 65 and over in Basildon is projected to rise steadily over the next decade, reflecting national longevity trends.
The council says its ‘taking a proactive, preventative approach to ensure Basildon remains an inclusive, accessible and sustainable place for residents of all ages’.
The strategy emphasises strong partnership working with health services, voluntary and community organisations, local businesses and residents.
Key commitments include:
- Supporting people to remain independent in their own homes for longer,
- Promoting age-friendly design in town centres and public spaces,
- Strengthening dementia-friendly communities,
- Expanding opportunities for volunteering and employment, and
- Continuing investment in activity centres and community-led initiatives that reduce loneliness.
Cllr Melissa McGeorge, cabinet member for ageing population & health, said: “Our ambition is clear: to make Basildon a place where people can age well, feel valued, and continue to thrive at every stage of later life.
The ‘Life Curve’
Meanwhile the London Borough of Richmond has launched a new self-assessment tool developed by ADL Research and Newcastle University to help boost longevity.
The ‘Life Curve’ tool is designed to support healthy ageing with personalised advice and practical steps on how to stay active and independent.
Councillor Allen, lead member for adult social care, said: “Getting older doesn’t have to mean we stop being independent and there are small steps we can take to help reduce how getting older limits our lives.
“We have tools and services available in the borough to support residents to take these small daily steps to maintain their health and reduce the risk of conditions like heart disease, cancer and dementia.
“A new tool accessible right from your phone or any other online device is ‘Independent Richmond’, which helps you understand where you are on The Life Curve to help stay on track with healthy habits, keeping active and stay independent for longer.”
News
Bryan Johnson launches US$1m longevity programme

Bryan Johnson has launched a US$1m-a-year longevity programme with just three places, offering access to the exact protocol he has followed for five years.
The programme, called “Immortals”, is offered by the former fintech entrepreneur, now a prominent and often controversial figure in longevity.
Johnson’s unconventional methods have included Botox injections in his genitals (Botox relaxes muscles) and transfusions of blood from his teenage son.
There is no evidence these will help him outlive others.
The “Immortals” package includes a dedicated concierge team, 24/7 access to the BryanAI health coach, extensive testing, continuous tracking of millions of biological data points and what Johnson calls the “best skin and hair protocols.
A lower-cost supported tier is available at US$60,000 per year.
Rivals also target the ultra-wealthy: Biograph’s premium membership costs US$15,000 per year, while Fountain Life’s “ultimate longevity programme” is priced at US$21,500 annually.
Despite the higher price, Johnson’s offer is built on exclusivity, with only three spots available.
News
Cognition and Cera expand Alzheimer’s clinical trials access

Cognition Health and Cera have partnered to expand access to Alzheimer’s clinical trials across the UK.
The collaboration links Re:Cognition Health’s specialist brain health clinics and trial expertise with Cera’s 2.5 million monthly home care visits, creating new pathways to identify and support people earlier in their health journey.
By connecting home care with specialist research centres, the partners aim to offer more people the chance to join studies, giving access to advanced assessment and emerging treatments while contributing to future therapies.
Dr Ben Maruthappu MBE, chief executive and founder of Cera, said: “Many older adults are currently ‘invisible’ to the clinical trials research system because they cannot access traditional clinic-centric recruitment.
“By enabling responsible, consented identification and screening within the home, we can bridge the gap between the community and the clinic.
“We are offering the older generation a seat at the table of global drug discovery, ensuring that the path to a cure starts where they are most comfortable—in their own daily lives.”
Re:Cognition Health has contributed to the development of lecanemab (Leqembi) and donanemab (Kisunla) through international trials, introducing disease-modifying approaches that are reshaping early intervention in Alzheimer’s care.
Older adults remain under-represented in research. NIHR data indicate only about 15 per cent of trial participants are 75 or older, despite high multimorbidity in this group. Dementia trial recruitment in the UK also lags other disease areas.
Through this collaboration, individuals who have not yet accessed specialist memory services can be referred earlier for assessment and potential study participation, with access to new-generation therapies where appropriate.
Cera’s technology-enabled home healthcare model, with daily patient contact and consented data capture, allows timely referral of potential participants from familiar settings to Re:Cognition Health clinics.
Together, the organisations will support earlier and more equitable participation by leveraging Cera’s scale and real-time insights. Carers and nurses deliver visits roughly every second on average, enabling early identification of those who may benefit from memory assessment.
Dr Emer MacSweeney, chief executive and founder of Re:Cognition Health, said: “With one in three people expected to develop dementia in their lifetime, it is essential that we create more inclusive and accessible routes into research.
“This collaboration enables us to extend our reach beyond traditional clinic settings and ensure that people who may benefit from early assessment and research participation are supported to do so.
“Clinical trials offer individuals access to the most advanced diagnostics and emerging treatments, alongside expert medical oversight.
“By identifying people earlier and guiding them through every stage of their journey, we can help improve participants’ experience and potential outcomes, while accelerating the development of the next generation of Alzheimer’s therapies.”
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