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Low sexual satisfaction in middle-aged men linked to future memory loss

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A fulfilling sex life in middle age could help reduce the risk of memory decline in later years.

A study led by scientists at Penn State University in Pennsylvania in the US tracked the correlation between erectile dysfunction, sexual satisfaction, and cognition in hundreds of men aged between 56 and 68.

It found that declines in sexual satisfaction and erectile function were associated with future memory loss. Lower erectile dysfunction in particular was linked to worse-than-usual cognitive performance and a decline in processing speed over time.

The study, published in the latest issue of the journal Gerontologist, is the first to longitudinally track sexual satisfaction in tandem with sexual health and cognition, the researchers said. Its findings point to a potential novel risk factor for cognitive decline.

Martin Sliwinski, professor of human development and family studies at Penn State and co-author on the study, said: “Scientists have found that if you have low satisfaction generally, you are at a higher risk for health problems like dementia, Alzheimer’s disease, cardiovascular disease and other stress-related issues that can lead to cognitive decline

“Improvements in sexual satisfaction may actually spark improvement in memory function. We tell people they should get more exercise and eat better foods. We’re showing that sexual satisfaction also has importance for our health and general quality of life.”

Riki Slayday, a doctoral candidate at Penn State and lead author on the study, added the findings show there is a connection between how a person feels about their sex life and their cognitive health.

She said: “Research on sexual health has historically focused on quantifiable facets of sexuality like number of sexual partners or frequency of sexual activity. What we were interested in is the perception of that activity, how someone feels about their sex life, and how that influences cognitive function, because multiple people could be in the same situation physically but experience completely different levels of satisfaction.”

The study explored the relationship between physical changes, like the microvascular alterations relevant for erectile function, and psychological variations, such as lower sexual satisfaction, to determine how the adjustments relate to cognition.

The team examined the shifts starting in middle age because it represents a transition period where declines in erectile function, cognition and sexual satisfaction begin to emerge.

Professor Sliwinski added that while the team discovered a strong correlation between the three health factors, they can only speculate as to the cause.

For the study, the researchers used survey data from 818 men who participated in the Vietnam Era Twin Study of Aging.

Through neuropsychological tests looking at the likes of memory and processing speed, they examined cognitive changes of participants over the 12-year span from age 56 to 68, adjusting for their brain-based skills in young adulthood.

Their erectile function and sexual satisfaction were measured alongside cognition, using the International Index of Erectile Function, a self-reported assessment for male sexual health. The researchers then built a statistical model to understand how the three variables changed as individuals aged.

The study found that decreases in erectile function and sexual satisfaction were both associated with memory decline, which the researchers said points to a connection between psychological and physical health.

Ms Slayday said: “When we mapped the relationship over time, we found increases or decreases in erectile function and sexual satisfaction were associated with concurrent increases or decreases in cognitive function. These associations survived adjustment for demographic and health factors, which tells us there is a clear connection between our sex lives and our cognition.”

Prior studies have found a link between microvascular changes and those noted in erectile function over time. In fact, the active ingredient in Viagra was originally developed to treat cardiovascular problems, so the connection between vascular health and erectile function is understood.

The researchers said how erectile function connects to other aspects of health should now be an area of focus for future study.

Increasing the assessment and monitoring of erectile function as a vital sign of health may help identify those at risk of cognitive decline before their 70s, Professor Sliwinski said.

The researchers noted that the older adult population in the US – as elsewhere across the globe – is expected to double over the next 30 years, meaning twice as many people will likely enter their 60s and experience declines in erectile function and sexual satisfaction.

Professor Sliwinski said: “We already have a pill for treating erectile dysfunction. What we don’t have is an effective treatment for memory loss. Instead of the conversation being about treating ED, we should see that as a leading indicator for other health problems and also focus on improving sexual satisfaction and overall well-being, not just treating the symptom.”

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Longevity startup Biopeak secures US$2.7m

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Longevity startup Biopeak has secured US$2.7m in a follow-on round led by NKSquared, the investment vehicle of Zerodha co-founder Nikhil Kamath.

This is Kamath’s second investment in the company after he put US$1.43m into the health optimisation startup in August 2024.

Founded in 2025 by Rishi Pardal and Shiva Subramanian, Biopeak operates India’s first specialised brand aimed at extending lifespans through preventive care.

It opened a clinic in Bengaluru last year and plans to open a second in the coming month.

The funds will be used to expand Biopeak’s operations, including the new clinic and enhancements to its diagnostics, proprietary artificial intelligence (AI) tools, research initiatives and clinical programmes, Pardal told ET. The startup also plans to hire for its clinical, research, product and operations teams while strengthening ties with global advisers for protocol development.

ET reported in June that the wellness and longevity startup raised US$3m in seed funding from Claypond Capital, the family office of Manipal Group chairman Ranjan Pai, Accel India cofounder Prashanth Prakash and existing investor Rainmatter, the investment arm of Zerodha.

Pardal said: “Since our last fundraise, we conclusively proved we can attract clients and deliver outcomes.

“Around August, we started our second flagship store while building capabilities in new diagnostic tests and AI-driven diagnosis for personalised programmes.

“All this requires investment to further validate product-market fit and scale our systems.”

Biopeak targets high achievers, executives and women, relying on programmes mixing advanced diagnostics, specialist teams, wearable data and AI insights tailored to Indian biology and disease patterns.

The model stresses early risk detection, longitudinal tracking and interventions to improve performance and resilience.

Over the past year, Biopeak has grown its client base and clinical offerings amid rising demand for structured longevity services.

Pardal said consumer attitudes towards proactive health are changing in India, but integrated systems linking diagnostics and follow-up remain scarce.

“Longevity and well-being interest is exploding across newspapers, social circles and web searches. People have intent and awareness.” the chief executive added.

The longevity sector is gaining momentum in the country as rising incomes and health awareness drive demand for preventive care beyond traditional episodic treatments.

With life expectancy surpassing 72 years but healthy life expectancy not catching up, such startups are tapping into a market projected to grow in the coming years on the back of India’s ageing population.

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Study reveals link between cheese and dementia

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A 25-year Swedish study links higher cheese intake to lower Alzheimer’s risk in people without known genetic risk, with cream also tied to lower dementia risk.

However, researchers emphasise that the results should be interpreted with caution.

The study tracked 27,670 people over 25 years.

During that time, 3,208 participants were diagnosed with dementia.

Among individuals without a known genetic risk for Alzheimer’s disease, those who consumed more than 50 grams of full-fat cheese per day showed a 13 to 17 per cent lower risk of developing Alzheimer’s.

This association did not appear in participants who carried genetic risk factors for the disease.

People who consumed more than 20 grams of full-fat cream per day also showed a lower risk of dementia overall, ranging from 16 to 24 per cent.

No meaningful links were found for low-fat or high-fat milk, fermented or non-fermented milk, or low-fat cream.

The results stand out because public health guidance has long encouraged people to choose low-fat dairy to protect heart health.

This connection matters because cardiovascular disease (conditions affecting the heart and blood vessels) and dementia share many underlying risk factors, including high blood pressure, diabetes and obesity.

When evidence from previous studies is combined, analyses suggest that cheese consumption may also be linked to a lower risk of heart disease, and that full-fat dairy does not necessarily increase cardiovascular risk.

Several other studies have explored whether similar patterns apply to brain health, but the results are mixed.

Evidence overall suggests that studies conducted in Asian populations are more likely to report benefits of dairy consumption for cognitive health (the ability to think, remember and reason), while many European studies do not.

One possible explanation is that average dairy intake tends to be much lower in Asian countries, meaning modest consumption may have different effects than higher intakes.

For example, one Japanese study reported a reduced dementia risk among people who ate cheese, but overall consumption levels were very low and the research was sponsored by a cheese producer.

In contrast, another Japanese study funded by government grants found no protective effect of cheese.

Some long-term European studies have also reported benefits.

In a Finnish study of 2,497 middle-aged men followed for 22 years, cheese was the only food associated with a lower dementia risk, reduced by 28 per cent.

Other dietary factors also appear to matter.

Higher consumption of milk and processed red meat was associated with worse performance on cognitive tests, while fish intake was linked to better results.

A large study in the UK that followed nearly 250,000 people found lower dementia risk among those who ate fish two to four times a week, fruit daily and cheese once a week.

However, these studies have important limitations.

What people eat is usually self-reported, and changes in memory can affect both eating habits and how accurately people remember what they have eaten. To deal with this, the Swedish researchers took two extra steps.

First, they excluded anyone who already had dementia when the study began.

Then they repeated the same calculations after removing people who went on to develop dementia within the first ten years of the study.

This did not mean starting the study again or recruiting new participants. It simply meant re-checking the results using a smaller group of people who remained dementia-free for longer.

The reason for doing this is that the early stages of dementia can subtly change behaviour long before diagnosis.

People may eat differently, lose appetite or struggle to recall their usual diet. By focusing on participants who stayed cognitively healthy for many years, the researchers reduced the chance that these early changes were influencing the results.

Another important question is whether substitution played a role.

Some of the apparent benefits may reflect replacing red or processed meat with cheese or cream, rather than an effect of dairy itself.

Supporting this idea, the Swedish study found no association between full-fat dairy and dementia risk among participants whose diets remained stable over five years.

Most importantly, foods should not be considered in isolation.

Dietary patterns matter more than individual ingredients. Diets such as the Mediterranean diet, which is consistently associated with lower risks of both dementia and heart disease, include cheese alongside vegetables, fish, whole grains and fruit.

In the Swedish study, people who consumed more full-fat cheese and cream were also more educated, less likely to be overweight and had lower rates of conditions linked to dementia, including heart disease, stroke, high blood pressure and diabetes.

All of these factors independently reduce dementia risk.

This suggests that higher cheese intake tended to occur within healthier overall lifestyles, rather than alongside excess calorie consumption or poor metabolic health.

Overall, the evidence does not support the idea that full-fat dairy causes dementia, nor that fermented milk products reliably protect against it.

Full-fat cheese contains several nutrients relevant to brain health, including fat-soluble vitamins A, D and K2, as well as vitamin B12, folate, iodine, zinc and selenium.

These nutrients play roles in neurological function and may help support cognitive health.

That said, the data do not justify eating large amounts of cheese or cream as protective foods against dementia or heart disease.

The most consistent message remains that balanced diets, moderation and overall lifestyle matter far more than any single item on the cheese board.

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New obesity and diabetes drug set for Boots clinical trial

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Boots will run an obesity drug trial for a new type 2 diabetes medicine at selected stores in England, the chain has revealed.

Boots has partnered with Civia Health to set up clinical research sites at four stores in Nottingham, Brighton, Peterborough and Birmingham, connecting communities to local research opportunities for obesity, diabetes and cardiovascular conditions.

Marc Donovan is director of healthcare development at Boots.

He said: “Clinical research plays a vital role in the development of new treatments and therapies, and we are proud to support increased clinical research participation to drive better health outcomes for all.”

The company said this is the first time dedicated clinical research units have been set up in high street pharmacies, enabling people to take part in convenient locations.

Boots said the first study to be conducted by Civia Health at its stores is a Phase 3 trial, a late-stage study that tests safety and effectiveness before approval, focused on a new obesity and type 2 diabetes medicine.

Customers at Boots stores will be able to join Civia Health’s longitudinal health registry, Thrive, which tracks participants’ health over time, and access free health screenings.

The screenings will include measurements such as height, weight, blood pressure and blood tests to help people understand their health and identify studies for which they may be eligible.

Civia will deploy its clinical teams, technology and operational standards to the participating Boots stores to screen and enrol participants, bringing research capability to the high street and providing convenient locations for study appointments.

As part of the partnership, Boots will also provide details of research opportunities to its customers to support recruitment.

Mark Campbell, chief executive of Civia Health, said: “For too long, clinical research sites have been in out-of-town and hard-to-find locations that can feel unfamiliar.

“Instead of relying on the small number of people who actively seek out studies, we’re bringing research to a broader, more diverse group – people who might benefit but would never have found us otherwise.”

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