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Low fitness in youth increases risk of middle age cardiometabolic disease

Low cardiorespiratory fitness in adolescence is associated with higher risk for cardiovascular and metabolic diseases in middle age, new research from Finland has found.
The extended follow-up study from researchers at the University of Jyväskylä provides real-life evidence for the far-reaching consequences of deteriorating fitness in youth.
The 45-year study combined the same participants’ fitness test data from adolescence (12–19 years) with information on diabetes, hypertension and coronary heart disease as well as self-measurements of waist circumference from the ages of 37 to 44 and/or 57 to 64 years.
The associations of cardiorespiratory, muscular and speed-agility fitness with the health conditions were investigated separately by combining the diseases and risk factors into a cardiometabolic risk score to indicate the burden of the conditions.
The study showed that low cardiorespiratory fitness in adolescence was associated with a higher burden of cardiometabolic conditions up to the age of 57 to 64 years.
Meanwhile, in females, low adolescent cardiorespiratory fitness increased the risk of hypertension in middle age, and in males, low speed-agility was associated with increased waist circumference in late middle age.
PhD student, Perttu Laakso, said: “Other common cardiometabolic disease risk factors such as age and body mass index were controlled for in the analyses, so we can conclude that cardiorespiratory fitness is an independent early indicator for cardiometabolic health later in life.”
The findings supplement previous evidence regarding mostly male participants such as a study on the data in the conscription register of the Swedish military.
Laakso said: “There have been publicly discussed concerns over how the deteriorating fitness of young people will affect the future labour force.
“This study gives us some scientific evidence to support that concern.
“Unfortunately, there is little sign of this concern being alleviated, given that the cardiorespiratory fitness level among today’s adolescents has been shown to be significantly lower than that of the adolescents examined in this study.”
The researcher emphasised that it is necessary to tackle all the barriers to young people’s physical activity, whether that means investing in an environment that encourages physical activity or human resources for organised youth sport.
Laakso said: “The economic cost of these investments will be far lower than the related healthcare or disability expenses caused by cardiometabolic diseases.”
Finally, Laakso stressed that even if person’s physical fitness in adolescence would not have been ideal, all is not lost.
“The evidence shows that exercising at all ages lowers the risk for cardiometabolic diseases.”
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Study reveals link between cheese and dementia

A 25-year Swedish study links higher cheese intake to lower Alzheimer’s risk in people without known genetic risk, with cream also tied to lower dementia risk.
However, researchers emphasise that the results should be interpreted with caution.
The study tracked 27,670 people over 25 years.
During that time, 3,208 participants were diagnosed with dementia.
Among individuals without a known genetic risk for Alzheimer’s disease, those who consumed more than 50 grams of full-fat cheese per day showed a 13 to 17 per cent lower risk of developing Alzheimer’s.
This association did not appear in participants who carried genetic risk factors for the disease.
People who consumed more than 20 grams of full-fat cream per day also showed a lower risk of dementia overall, ranging from 16 to 24 per cent.
No meaningful links were found for low-fat or high-fat milk, fermented or non-fermented milk, or low-fat cream.
The results stand out because public health guidance has long encouraged people to choose low-fat dairy to protect heart health.
This connection matters because cardiovascular disease (conditions affecting the heart and blood vessels) and dementia share many underlying risk factors, including high blood pressure, diabetes and obesity.
When evidence from previous studies is combined, analyses suggest that cheese consumption may also be linked to a lower risk of heart disease, and that full-fat dairy does not necessarily increase cardiovascular risk.
Several other studies have explored whether similar patterns apply to brain health, but the results are mixed.
Evidence overall suggests that studies conducted in Asian populations are more likely to report benefits of dairy consumption for cognitive health (the ability to think, remember and reason), while many European studies do not.
One possible explanation is that average dairy intake tends to be much lower in Asian countries, meaning modest consumption may have different effects than higher intakes.
For example, one Japanese study reported a reduced dementia risk among people who ate cheese, but overall consumption levels were very low and the research was sponsored by a cheese producer.
In contrast, another Japanese study funded by government grants found no protective effect of cheese.
Some long-term European studies have also reported benefits.
In a Finnish study of 2,497 middle-aged men followed for 22 years, cheese was the only food associated with a lower dementia risk, reduced by 28 per cent.
Other dietary factors also appear to matter.
Higher consumption of milk and processed red meat was associated with worse performance on cognitive tests, while fish intake was linked to better results.
A large study in the UK that followed nearly 250,000 people found lower dementia risk among those who ate fish two to four times a week, fruit daily and cheese once a week.
However, these studies have important limitations.
What people eat is usually self-reported, and changes in memory can affect both eating habits and how accurately people remember what they have eaten. To deal with this, the Swedish researchers took two extra steps.
First, they excluded anyone who already had dementia when the study began.
Then they repeated the same calculations after removing people who went on to develop dementia within the first ten years of the study.
This did not mean starting the study again or recruiting new participants. It simply meant re-checking the results using a smaller group of people who remained dementia-free for longer.
The reason for doing this is that the early stages of dementia can subtly change behaviour long before diagnosis.
People may eat differently, lose appetite or struggle to recall their usual diet. By focusing on participants who stayed cognitively healthy for many years, the researchers reduced the chance that these early changes were influencing the results.
Another important question is whether substitution played a role.
Some of the apparent benefits may reflect replacing red or processed meat with cheese or cream, rather than an effect of dairy itself.
Supporting this idea, the Swedish study found no association between full-fat dairy and dementia risk among participants whose diets remained stable over five years.
Most importantly, foods should not be considered in isolation.
Dietary patterns matter more than individual ingredients. Diets such as the Mediterranean diet, which is consistently associated with lower risks of both dementia and heart disease, include cheese alongside vegetables, fish, whole grains and fruit.
In the Swedish study, people who consumed more full-fat cheese and cream were also more educated, less likely to be overweight and had lower rates of conditions linked to dementia, including heart disease, stroke, high blood pressure and diabetes.
All of these factors independently reduce dementia risk.
This suggests that higher cheese intake tended to occur within healthier overall lifestyles, rather than alongside excess calorie consumption or poor metabolic health.
Overall, the evidence does not support the idea that full-fat dairy causes dementia, nor that fermented milk products reliably protect against it.
Full-fat cheese contains several nutrients relevant to brain health, including fat-soluble vitamins A, D and K2, as well as vitamin B12, folate, iodine, zinc and selenium.
These nutrients play roles in neurological function and may help support cognitive health.
That said, the data do not justify eating large amounts of cheese or cream as protective foods against dementia or heart disease.
The most consistent message remains that balanced diets, moderation and overall lifestyle matter far more than any single item on the cheese board.
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