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Insilico in US$66m deal for Parkinson’s drug

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Insilico Medicine has agreed a US$66m deal with a Chinese biotech for half of the rights to a brain-penetrant Parkinson’s drug.

Under the agreement, the artificial intelligence-powered drug developer will take the lead on bringing the preclinical asset, dubbed ISM8969, into a phase 1 trial.

Hygtia Therapeutics will then take over for further studies and onward toward regulators and commercialisation.

Ren Feng is co-chief executive and chief scientific officer at Insilico.

Feng said: “Targeting neuroinflammation via NLRP3 represents a scientifically sound and high-potential approach to treating neurodegenerative and age-related diseases.

“However, developing a safe molecule with good blood-brain barrier penetration remains a formidable obstacle for drug developers.

“Through our generative AI platform, we have designed a molecule specifically engineered to overcome this barrier.

“We are pleased to partner with Hygtia Therapeutics.

“We believe that through our combined efforts, we can accelerate its clinical progress to address significant unmet medical needs.”

ISM8969 is an NLRP3 inhibitor.

NLRP3 is a protein involved in inflammation, and blocking it is being explored as a way to address a range of neuroinflammatory and cardiometabolic diseases. Interest in NLRP3 inhibition has increased in the past year.

Earlier this month, Eli Lilly paid US$1.2bn to acquire Ventyx Biosciences in the wake of a phase 2 study tying Ventyx’s lead NLRP3 inhibitor to improvements in Parkinson’s symptoms.

That same NLRP3 inhibitor had also been shown to cut levels of a biomarker for stroke and other serious risks by almost 80 per cent within a week in a separate mid-stage study.

Preclinical data for ISM8969 have “demonstrated the molecule’s robust efficacy, favourable safety profile and marked anti-inflammatory activity in various disease models,” said Insilico, which also noted the therapy’s “desirable blood-brain barrier penetration.”

The blood-brain barrier is the protective barrier around the brain that many drugs struggle to cross.

Insilico, which went public on the Hong Kong Stock Exchange last month, said it had discovered ISM8969 via its generative chemistry engine Chemistry42.

As well as an upfront fee of US$10m, Insilico is in line for up to US$56m in milestone payments from Hygtia.

Insilico has attracted interest from pharmaceutical companies for its AI-enabled drug discovery technology, including Sanofi, Pfizer, Menarini Group and Boehringer Ingelheim.

Most recently, Lilly agreed a deal worth more than US$100m in November.

Hygtia, which was founded last August after being incubated by Fosun Pharma, said the agreement with Insilico “marks a pivotal step in our global strategy.

This partnership aligns with our strategy to expand our innovative neuroscience pipeline through high-quality assets.”

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Agetech investment & innovation round-up

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Two London boroughs have launched their own initiatives aimed at supporting their ageing resident populations. 

Long-term gut health and female finance, London likes longevity

New York innovator Salvo Health has secured $8.5m in Series A round as it looks to develop new, long-term, gut-health treatments.

The funding round was led by ManchesterStory, City Light Capital and Threshold Ventures, with additional support from The Artemis Fund, Owl Capital, Impact X Capital Partners, Torch Capital and Felicis Ventures. 

Eric Collins, co-founder and general partner of Impact X Capital Partners, a UK-based venture capital firm, said: “The key with Salvo is patient-centred care.

“It’s critical to expand access to food as medicine and behavioural health to improve outcomes and lower, long-term health care costs.

“Salvo does exactly that and has shown 76 per cent of patients report improved symptoms, with five accepted abstracts on outcomes, and a 79 per cent drop in GI-related ER utilisation for its patients.

“We can have better care at lower costs with innovation, in the US, and ultimately in the UK and Europe as well.”

The raise brings Salvo’s total equity funding to US$21.6m. Roughly 60m Americans experience chronic gastrointestinal conditions each year.

Salvo Health is positioning itself in the space between overburdened clinics and patients’ everyday lives.

Female longevity in focus

Xella Health – a women’s precision platform focused on fertility, ageing, and body changes – has raised over US$3.7m in pre-seed funding.

The funds will support product finalisation, partnerships, and a Spring 2026 launch, focused on sex-specific longevity and preventive care.

The round was led by Precursor Ventures, with participation from Capital F, Ulu Ventures, and other funds, as well as, strategic angel investors across healthcare, diagnostics, and consumer technology.

Xella is aiming to propel women’s health beyond symptom-based care and fragmented testing to deliver ‘integrated biological insight, clarity, and foresight’. 

The company combines advanced diagnostics, longitudinal data, and personalised clinician-led guidance to help women understand what’s happening in their bodies today – and what lies ahead – across fertility, chronic conditions, hormonal health, early cancer detection, and preventative care.

“Our mission is to give women the answers and care they have always deserved,” said Kelly Lacob, co-founder & CEO of Xella.

“Xella is building the infrastructure to decode female biology – getting to the root cause of conditions that uniquely, differently or disproportionately affect women, many of which suffer from an unacceptably poor standard of care today.”

“Xella is rethinking women’s health from the ground up – starting with the insight women need to make sense of their own biology over time,” said Ashtan Jordan, principal at Precursor Ventures. 

Age well in London

Two London boroughs have launched their own initiatives aimed at supporting their ageing resident populations. 

Basildon Council has approved a new Ageing Population Strategy to support older residents live healthy, independent and connected lives.

The number of residents aged 65 and over in Basildon is projected to rise steadily over the next decade, reflecting national longevity trends.

The council says its ‘taking a proactive, preventative approach to ensure Basildon remains an inclusive, accessible and sustainable place for residents of all ages’.

The strategy emphasises strong partnership working with health services, voluntary and community organisations, local businesses and residents.

Key commitments include:

  •       Supporting people to remain independent in their own homes for longer,
  •       Promoting age-friendly design in town centres and public spaces,
  •       Strengthening dementia-friendly communities,
  •       Expanding opportunities for volunteering and employment, and
  •       Continuing investment in activity centres and community-led initiatives that reduce loneliness.

Cllr Melissa McGeorge, cabinet member for ageing population & health, said: “Our ambition is clear: to make Basildon a place where people can age well, feel valued, and continue to thrive at every stage of later life.

The ‘Life Curve’

Meanwhile the London Borough of Richmond has launched a new self-assessment tool developed by ADL Research and Newcastle University to help boost longevity.

The ‘Life Curve’ tool is designed to support healthy ageing with personalised advice and practical steps on how to stay active and independent.

Councillor Allen, lead member for adult social care, said: “Getting older doesn’t have to mean we stop being independent and there are small steps we can take to help reduce how getting older limits our lives.

“We have tools and services available in the borough to support residents to take these small daily steps to maintain their health and reduce the risk of conditions like heart disease, cancer and dementia. 

“A new tool accessible right from your phone or any other online device is ‘Independent Richmond’, which helps you understand where you are on The Life Curve to help stay on track with healthy habits, keeping active and stay independent for longer.” 

 

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Bryan Johnson launches US$1m longevity programme

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Bryan Johnson has launched a US$1m-a-year longevity programme with just three places, offering access to the exact protocol he has followed for five years.

The programme, called “Immortals”, is offered by the former fintech entrepreneur, now a prominent and often controversial figure in longevity.

Johnson’s unconventional methods have included Botox injections in his genitals (Botox relaxes muscles) and transfusions of blood from his teenage son.

There is no evidence these will help him outlive others.

The “Immortals” package includes a dedicated concierge team, 24/7 access to the BryanAI health coach, extensive testing, continuous tracking of millions of biological data points and what Johnson calls the “best skin and hair protocols.

A lower-cost supported tier is available at US$60,000 per year.

Rivals also target the ultra-wealthy: Biograph’s premium membership costs US$15,000 per year, while Fountain Life’s “ultimate longevity programme” is priced at US$21,500 annually.

Despite the higher price, Johnson’s offer is built on exclusivity, with only three spots available.

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Cognition and Cera expand Alzheimer’s clinical trials access

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Cognition Health and Cera have partnered to expand access to Alzheimer’s clinical trials across the UK.

The collaboration links Re:Cognition Health’s specialist brain health clinics and trial expertise with Cera’s 2.5 million monthly home care visits, creating new pathways to identify and support people earlier in their health journey.

By connecting home care with specialist research centres, the partners aim to offer more people the chance to join studies, giving access to advanced assessment and emerging treatments while contributing to future therapies.

Dr Ben Maruthappu MBE, chief executive and founder of Cera, said: “Many older adults are currently ‘invisible’ to the clinical trials research system because they cannot access traditional clinic-centric recruitment.

“By enabling responsible, consented identification and screening within the home, we can bridge the gap between the community and the clinic.

“We are offering the older generation a seat at the table of global drug discovery, ensuring that the path to a cure starts where they are most comfortable—in their own daily lives.”

Re:Cognition Health has contributed to the development of lecanemab (Leqembi) and donanemab (Kisunla) through international trials, introducing disease-modifying approaches that are reshaping early intervention in Alzheimer’s care.

Older adults remain under-represented in research. NIHR data indicate only about 15 per cent of trial participants are 75 or older, despite high multimorbidity in this group. Dementia trial recruitment in the UK also lags other disease areas.

Through this collaboration, individuals who have not yet accessed specialist memory services can be referred earlier for assessment and potential study participation, with access to new-generation therapies where appropriate.

Cera’s technology-enabled home healthcare model, with daily patient contact and consented data capture, allows timely referral of potential participants from familiar settings to Re:Cognition Health clinics.

Together, the organisations will support earlier and more equitable participation by leveraging Cera’s scale and real-time insights. Carers and nurses deliver visits roughly every second on average, enabling early identification of those who may benefit from memory assessment.

Dr Emer MacSweeney, chief executive and founder of Re:Cognition Health, said: “With one in three people expected to develop dementia in their lifetime, it is essential that we create more inclusive and accessible routes into research.

“This collaboration enables us to extend our reach beyond traditional clinic settings and ensure that people who may benefit from early assessment and research participation are supported to do so.

“Clinical trials offer individuals access to the most advanced diagnostics and emerging treatments, alongside expert medical oversight.

“By identifying people earlier and guiding them through every stage of their journey, we can help improve participants’ experience and potential outcomes, while accelerating the development of the next generation of Alzheimer’s therapies.”

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