Connect with us

News

Corsera Health raises US$80m to prevent heart disease

Published

on

Corsera Health has raised US$80m in Series A funding to develop preventive RNAi medicines and AI tools to predict and prevent cardiovascular disease.

The Boston-based company has begun dosing patients in a Phase 1 clinical trial of COR-1004, a drug designed to lower cholesterol by silencing PCSK9, a gene that regulates LDL cholesterol in the blood.

Corsera is developing medicines using RNA interference (RNAi), which silences specific genes to reduce disease-causing proteins.

Its approach targets elevated LDL cholesterol and high blood pressure, the two main drivers of atherosclerotic cardiovascular disease, where plaque builds up in artery walls.

The medicines are designed for once-annual administration to enable broad access.

Clive Meanwell, co-founder and co-chief executive of Corsera Health, said: “At Corsera, we are motivated by a bold vision: a world without cardiovascular disease.

“We are making strong progress towards a future in which preventive care enables people to live longer, healthier lives, and the initiation of our first clinical trial marks an important milestone on that journey.”

The Series A round was co-led by Forbion and Population Health Partners.

The company expects initial proof-of-concept data in 2026, with a second Phase 1 trial anticipated to begin in mid-2026.

John Maraganore, co-founder and co-chief executive of Corsera Health, said: “By combining AI-enabled prediction of lifetime ASCVD risk with preventive RNAi medicines, Corsera has the potential to change the trajectory of cardiovascular disease, enabling earlier intervention and broad access to prevention at a population scale.”

Wellness

Older male athletes may face increased risk of serious heart problems during exercise

Published

on

Veteran male athletes may face higher heart risk during exercise if they have existing heart scarring, new research suggests.

The study found that male endurance athletes aged over 50 were more likely to experience abnormal heart rhythms during training if scarring was present.

Nine in 10 sudden cardiac deaths during sport occur in older male athletes.

Researchers at the University of Leeds tracked 106 healthy male endurance athletes aged over 50 who had been doing more than 10 hours of running or cycling weekly for at least 15 years.

They matched training data from wearables with implantable loop recorders to align heart rhythms with activity.

Over two years, about one in four participants experienced ventricular tachycardia, a fast, abnormal rhythm arising from the heart’s lower chambers, during or just after exercising.

Three quarters of those who had these episodes had heart scarring. There were three sustained episodes during exercise, all in athletes with scarring.

Scarring may be caused by heart attacks, disease or cumulative exertion from years of high-intensity exercise.

Dr Wasim Javed, research fellow at the University of Leeds and lead author, said: “Our study shows that exercise was only associated with a risk of developing abnormal heart rhythms in those who were already high risk due to heart scarring.

“Athletes who developed abnormal heart rhythms were not exercising more or harder than athletes without abnormal heart rhythms.

“This suggests that exercise itself is not the cause, but could act as a trigger for dangerous heart rhythms in those athletes already with an underlying heart issue.”

“Exercise is safe and has immense benefits – but athletes in this group should have regular health checks to make sure they stay healthy.”

The researchers said their findings support the use of wearable technology for athletes who want to monitor their heart rate for unusual activity.

Continue Reading

News

Childhood exposure to indoor air pollution linked to long term brain harms

Published

on

Childhood exposure to indoor air pollution may have long-term effects on brain health, with cognitive impairment appearing decades later, new research suggests.

The study analysed data from over 7,000 Chinese adults aged 45 and above using machine learning techniques.

Nearly 30 per cent of the global population, roughly 2.4bn people, still cook without clean fuels such as gas or electricity, instead using solid fuels like coal, wood and plant waste.

Researchers at the University of Helsinki found that individuals exposed as children to indoor air pollution from solid fuels performed significantly worse on cognitive tests in adulthood, particularly in episodic memory and overall mental health.

The study identified two main pathways through which childhood exposure may contribute to poorer cognitive performance: biological, including being overweight and limitations in daily activities; and socioeconomic, with exposure associated with lower education and income levels.

Men, smokers and regular alcohol users were particularly vulnerable to the detrimental effects.

Xu Zong, the study’s author, said: “Our study emphasises that early exposure to air pollution affects later cognitive health through both biological and social pathways.

“That is why public health efforts should combine clean energy initiatives with preventive strategies that support lifelong health and positive behaviours.

“Switching to cleaner fuels, such as gas or electricity, is not merely an environmental or respiratory health measure.

“It is also an investment in long-term cognitive wellbeing that could safeguard brain health for future generations.”

Continue Reading

News

SimpleC launches AI companion for dementia carers

Published

on

SimpleC has launched Wellby, an AI companion for unpaid dementia carers, offering round-the-clock emotional support and practical guidance.

Announced at CES in Las Vegas, Wellby is designed for caregivers of people with Alzheimer’s disease and related dementias.

Some 63 million people in the US provide unpaid care to older adults, including 12 million specifically caring for those with dementia. SimpleC says many face emotional strain, uncertainty and limited timely guidance.

Unlike general-purpose AI tools, Wellby is built for caregiving support, delivering personalised, real-time assistance through natural conversation.

Kevin Henze, chief executive of SimpleC, said: “This launch reinforces our belief that technology should support caregivers with both intelligence and compassion.

“As a privately owned, mission-driven company, we’re able to prioritise affordability, accessibility, and long-term caregiver impact. Wellby represents technology with soul—AI designed to truly walk alongside caregivers.”

Future releases will integrate the companion into SimpleC’s Connected Care Platform and extend it to serve older adults ageing in place.

Jun Ying, chief product officer, said: “By integrating AI across our platform, we’re creating a connected ecosystem where caregivers and care recipients can access multiple services—support, monitoring, guidance, and coordination—through a single, trusted SimpleC experience.”

Continue Reading

Trending

Agetech World