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Billionaire Platt backs Engitix again with US$25m

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London-based biotech Engitix has raised US$25m in a Series A extension, with billionaire hedge fund founder Mike Platt backing the company for the second time.

The preclinical company is developing therapies that target the extracellular matrix (ECM), the structural material surrounding cells in tissues, in solid tumours and fibrosis.

Founder Giuseppe Mazza said the company chose to present the funding as an extension rather than a new round to match its current stage.

“We are still preclinical and want the financing label to match the company’s current stage; the series B is intended to be the step-up round once we are ready to enter the clinic and pursue clinical proof-of-concept, which typically supports a larger raise,” he said.

The extension was led by Netherton Investments, which invests on behalf of Platt, co-founder of BlueCrest Capital Management. Platt also co-led the company’s US$54m Series A in 2022.

Mazza said: “We target disease-specific changes in the extracellular matrix, which is the abnormal tissue environment that actively drives both cancer and fibrosis. In oncology, patients with desmoplastic tumours have particularly poor outcomes because the dense tumour matrix limits the effectiveness of current treatments.

“By targeting disease-specific ECM changes, we can anchor therapies directly to tumour tissue in hard-to-treat, desmoplastic cancers and aim to actively clear established scar tissue in fibrosis.”

Engitix has three disclosed preclinical programmes and two confidential collaborative programmes with Takeda.

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Older male athletes may face increased risk of serious heart problems during exercise

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Veteran male athletes may face higher heart risk during exercise if they have existing heart scarring, new research suggests.

The study found that male endurance athletes aged over 50 were more likely to experience abnormal heart rhythms during training if scarring was present.

Nine in 10 sudden cardiac deaths during sport occur in older male athletes.

Researchers at the University of Leeds tracked 106 healthy male endurance athletes aged over 50 who had been doing more than 10 hours of running or cycling weekly for at least 15 years.

They matched training data from wearables with implantable loop recorders to align heart rhythms with activity.

Over two years, about one in four participants experienced ventricular tachycardia, a fast, abnormal rhythm arising from the heart’s lower chambers, during or just after exercising.

Three quarters of those who had these episodes had heart scarring. There were three sustained episodes during exercise, all in athletes with scarring.

Scarring may be caused by heart attacks, disease or cumulative exertion from years of high-intensity exercise.

Dr Wasim Javed, research fellow at the University of Leeds and lead author, said: “Our study shows that exercise was only associated with a risk of developing abnormal heart rhythms in those who were already high risk due to heart scarring.

“Athletes who developed abnormal heart rhythms were not exercising more or harder than athletes without abnormal heart rhythms.

“This suggests that exercise itself is not the cause, but could act as a trigger for dangerous heart rhythms in those athletes already with an underlying heart issue.”

“Exercise is safe and has immense benefits – but athletes in this group should have regular health checks to make sure they stay healthy.”

The researchers said their findings support the use of wearable technology for athletes who want to monitor their heart rate for unusual activity.

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Childhood exposure to indoor air pollution linked to long term brain harms

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Childhood exposure to indoor air pollution may have long-term effects on brain health, with cognitive impairment appearing decades later, new research suggests.

The study analysed data from over 7,000 Chinese adults aged 45 and above using machine learning techniques.

Nearly 30 per cent of the global population, roughly 2.4bn people, still cook without clean fuels such as gas or electricity, instead using solid fuels like coal, wood and plant waste.

Researchers at the University of Helsinki found that individuals exposed as children to indoor air pollution from solid fuels performed significantly worse on cognitive tests in adulthood, particularly in episodic memory and overall mental health.

The study identified two main pathways through which childhood exposure may contribute to poorer cognitive performance: biological, including being overweight and limitations in daily activities; and socioeconomic, with exposure associated with lower education and income levels.

Men, smokers and regular alcohol users were particularly vulnerable to the detrimental effects.

Xu Zong, the study’s author, said: “Our study emphasises that early exposure to air pollution affects later cognitive health through both biological and social pathways.

“That is why public health efforts should combine clean energy initiatives with preventive strategies that support lifelong health and positive behaviours.

“Switching to cleaner fuels, such as gas or electricity, is not merely an environmental or respiratory health measure.

“It is also an investment in long-term cognitive wellbeing that could safeguard brain health for future generations.”

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SimpleC launches AI companion for dementia carers

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SimpleC has launched Wellby, an AI companion for unpaid dementia carers, offering round-the-clock emotional support and practical guidance.

Announced at CES in Las Vegas, Wellby is designed for caregivers of people with Alzheimer’s disease and related dementias.

Some 63 million people in the US provide unpaid care to older adults, including 12 million specifically caring for those with dementia. SimpleC says many face emotional strain, uncertainty and limited timely guidance.

Unlike general-purpose AI tools, Wellby is built for caregiving support, delivering personalised, real-time assistance through natural conversation.

Kevin Henze, chief executive of SimpleC, said: “This launch reinforces our belief that technology should support caregivers with both intelligence and compassion.

“As a privately owned, mission-driven company, we’re able to prioritise affordability, accessibility, and long-term caregiver impact. Wellby represents technology with soul—AI designed to truly walk alongside caregivers.”

Future releases will integrate the companion into SimpleC’s Connected Care Platform and extend it to serve older adults ageing in place.

Jun Ying, chief product officer, said: “By integrating AI across our platform, we’re creating a connected ecosystem where caregivers and care recipients can access multiple services—support, monitoring, guidance, and coordination—through a single, trusted SimpleC experience.”

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