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An international research mission to identify and harness genetic variants that potentially stave off early-onset Alzheimer's made fresh progress, it reports in a new study. Five years ago, the global team of researchers identified a patient who did not develop cognitive impairment until her late 70s, despite being part of a family at extremely high genetic [...]
Osteoporosis is a skeletal condition that leads to the weakening of bones, making them porous, fragile, and prone to breakage. A massive 8.9 million fractures are caused by osteoporosis annually, with one fracture occurring every three seconds. The ageing population is the most vulnerable to primary osteoporosis, given, their frailty, and often, requires long-term therapy [...]
The ketogenic diet has its fanatics and detractors among dieters, but either way, the diet has a scientifically documented impact on memory in mice. While uncovering how the high fat, low carbohydrate diet boosts memory in older mice, Buck scientists and a team from the University of Chile identified a new molecular signalling pathway that [...]
A 16-week Plants for Joints trial investigated the effects of a multidisciplinary lifestyle intervention in people with rheumatoid arthritis (RA), as compared to usual care. The intervention was based on a whole-food, plant-based diet – alongside physical activity and stress management. Previous reports showed this intervention significantly reduced the 28-joint disease activity score compared to [...]
A new study has investigated the relationship between brain topological resilience (BTR), ageing, vascular risk factors, atherosclerosis, and cognition in middle-aged and older adults. Existing research indicates that cognitive impairment in late life is the result of a sequence of life-long events, with vascular risk factors playing a crucial role in this process. It is [...]
Results from a new study have shown an analogous shift in exploration behaviour in middle age for the first time in humans. Spatial navigation – the ability to select and follow a route from one place to another – is a skill we use every day. Depending on practice, general cognitive ability, and childhood environment, [...]
Findings from a new study suggest that changes to the gut microbiome play a role in the systemwide inflammation that often occurs with ageing. When scientists transplanted the gut microbes of aged mice into young “germ-free” mice — raised to have no gut microbes of their own — the recipient mice experienced an increase in [...]
Among US veterans diagnosed with lung cancer through the Veterans Health Administration healthcare system, those who underwent screening before diagnosis were more likely to be diagnosed with earlier stage disease and had a higher cure rate than those who had not been screened. Lung cancer is the leading cause of cancer deaths worldwide, and most [...]
Cirrus Therapeutics, the University of Bristol, and London’s Global University Institute of Ophthalmology have discovered a revolutionary treatment for age-related macular degeneration (AMD), the leading cause of vision loss among older adults. Featured on the cover of the journal Science Translational Medicine, this breakthrough research reveals that boosting a specific protein, IRAK-M, in retinal cells [...]
A collaboration between Cirrus Therapeutics, the University of Bristol, and London’s Global University Institute of Ophthalmology have discovered a revolutionary treatment for age-related macular degeneration (AMD), the leading cause of vision loss among older adults. Featured on the cover of the journal Science Translational Medicine, this breakthrough research reveals that boosting a specific protein, IRAK-M, in [...]
