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The Ministry of Health and Prevention in the United Arab Emirates (UAE) has approved Leqembi (lecanemab) an Alzheimer's treatment - where 4.09% of those over 60 years old have dementia. Leqembi's approval in the UAE is based on a large global Phase 3 Clarity AD study in which Leqembi met its primary endpoint and all [...]
WHO Europe is to host a webinar on 17 September to explore the intersection of healthy ageing and digital health. As the global population ages, ensuring the health and wellbeing of older adults becomes increasingly urgent. The United Nations estimates that the population aged over 60 years will reach 2.1 billion by 2050, nearly doubling [...]
New research has revealed that people aged 60 and older with untreated high blood pressure may have an increased risk of Alzheimer’s disease. This is compared to both people who have been or are being treated for high blood pressure as well as people without the chronic condition. Author Matthew J. Lennon, MD, PhD, of [...]
A new study has revealed huge biomolecular shifts that contribute to age-related changes in our 40s and 60s. Rather than changing in a gradual manner, researchers have discovered that molecules and microorganisms contained in our body undergo two periods of rapid change at around age 44 and age 60. For the study, researchers analysed the [...]
A new animal study has found a way to restore the brain's waste-clearing process in mice, offering a potential treatment strategy for neurological disorders where the brain struggles to clear out harmful waste such as Alzheimer’s and Parkinson’s. Ageing is a key risk factor for diseases such as Alzheimer’s and Parkinson’s because, as we age, [...]
In a new animal study, researchers have demonstrated how a treatment could lengthen both life span and vigour all the way until death. The study describes how a group of mice lived 9% longer when they received monthly treatments, or about 79 extra days of life. Equally, the study found that the mice demonstrated that [...]
Older age, female sex, irregular heart rhythms, and daily activity levels can help to predict how much Alzheimer’s Disease patients’ cognitive function will decline, according to research. Researchers set out to understand which patient characteristics might best predict cognitive decline in Alzheimer's, following an initial cohort of 500 Austrian patients with probable and possible Alzheimer’s Disease [...]
A relatively new type of degenerative brain disease which was recognised a decade ago is affecting as many as one in two individuals over 85, research suggests. Limbic-predominant age-related TDP-43 encephalopathy (LATE), was first recognised around 10 years ago, and remains relatively unknown. In the disease, the TDP-43 protein accumulates particularly in the limbic brain [...]
New light has been shed on the mechanisms behind memory updating and how those mechanisms can go awry with age. A team of US researchers has identified an enzyme that contributes to age-related impairments in memory updating. When blocked, older mice were better able to incorporate new information and performed similarly to their younger counterparts. [...]
New findings from exploratory analysis of Amylyx Pharmaceuticals' PEGASUS trial provide preliminary evidence that AMX0035 engages multiple pathological pathways related to neurodegeneration, including tau, resulting in consistent changes in Alzheimer’s Disease and neurodegeneration cerebrospinal fluid (CSF) biomarkers. The researchers suggest that AMX0035 - odium phenylbutyrate [PB] and taurursodiol [TURSO] - engages important pathways implicated in [...]
