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A new study found that a gene recently recognised as a biomarker for Alzheimer’s disease is actually a cause of it, due to its previously unknown secondary function - and have used artificial intelligence to help unravel this mystery of Alzheimer’s disease and discover a potential treatment that obstructs the gene’s moonlighting role. About one [...]
Researchers have uncovered crucial evidence that substance use disorders (SUDs) accelerate biological ageing in the brain through distinct molecular mechanisms. The groundbreaking study examines how different substances, such as alcohol, opioids, and stimulants, affect the brain's ageing process at the molecular level, potentially explaining why individuals with SUDs often experience early-onset age-related diseases. The research [...]
A common diabetes drug can reduce the pain of people with knee osteoarthritis and overweight or obesity, possibly delaying the need for knee replacements, new research has found. Metformin, which is commonly prescribed to treat type 2 diabetes, reduced knee arthritis pain over six months in a clinical trial. The randomised clinical trial looked at [...]
Researchers have developed a technology that enables the diagnosis of osteoarthritis and rheumatoid arthritis within 10 minutes using synovial fluid. According to some studies, over 50 per cent of the population aged 65 and older experience symptoms of osteoarthritis, while rheumatoid arthritis is known to be a serious chronic disease that affects approximately one in [...]
Researchers have discovered that expansion of mutant blood cells, a phenomenon linked to ageing, can be found in cancerous tumours, and this is associated with worse outcomes for patients. Understanding the biological interface of age-related genetic changes and diseases of ageing, such as cancer and cardiovascular disease, is important to develop preventative therapies for a [...]
Researchers have found that both low and moderate-high intensity exercise could be valuable tools in the fight against Alzheimer’s. The new research describes the results of the EXERT study (Exercise in Adults with Mild Memory Problems), a multi-site clinical trial of lower or moderate-high intensity exercise in sedentary older adults with amnestic mild cognitive impairment, [...]
New research has revealed that a patient’s muscle quality before total hip arthroplasty may predict their risk of such suboptimal recovery after surgery. Hip replacement surgery, or total hip arthroplasty (THA), can lessen pain and improve function in individuals with hip osteoarthritis, but some patients continue to experience long-term physical deficits - including muscle weakness, [...]
A study has identified immune resilience as a key driver of salutogenesis — the active process of promoting health and well-being. By analysing data from 17,500 individuals across various life stages, investigators uncovered the importance of immune resilience involving TCF7, a gene essential for maintaining immune cell regenerative potential, in fostering healthy ageing and longevity. [...]
Researchers have discovered a new way to measure changes in DNA that can help predict a person’s age using a method that focuses on how random certain chemical tags on DNA become over time. The method focuses on how random certain chemical tags on DNA become over time. The team compared this new measurement, called [...]
As we age, blood stem cells, the essential source of new blood cells in the body, can accumulate genetic mutations. These mutations can give the cells a growth advantage, laying the foundation for developing serious health conditions. Now, scientists have not only discovered the mechanism that fuels their unchecked growth but have also found a [...]
