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The USC Clinical Trial Recruitment Lab will fund four projects testing how AI can strengthen recruitment for Alzheimer's trials. The initiative, dedicated to accelerating and improving Alzheimer's clinical trials, selected the projects from more than 30 applicants to explore digital approaches. Alzheimer's clinical trials are more complex, costlier and take longer than those in other [...]
Insilico Medicine has agreed a US$66m deal with a Chinese biotech for half of the rights to a brain-penetrant Parkinson's drug. Under the agreement, the artificial intelligence-powered drug developer will take the lead on bringing the preclinical asset, dubbed ISM8969, into a phase 1 trial. Hygtia Therapeutics will then take over for further studies and [...]
Scientists have developed a nanoparticle strategy to broaden which disease-causing proteins medicines can target, giving options for dementia and brain cancer. A perspective outlines an approach designed to remove harmful proteins that drive disease. By broadening the proteins that can be treated, the technology could help tackle conditions such as dementia and brain cancer. The [...]
Exciva has raised US$59.4m in series B funding to support a phase 2 trial of its Alzheimer's therapy. The clinical-stage biopharmaceutical company is developing treatments for behavioural symptoms associated with the condition. Neuropsychiatric symptoms such as agitation and other behavioural symptoms affect up to 90 per cent of patients with severe Alzheimer's disease, driving caregiver [...]
SciNeuro Pharmaceuticals has entered a worldwide licensing and collaboration agreement with Novartis to advance its amyloid beta-targeted antibody programme for Alzheimer's disease. The programme has identified de novo antibody candidates that incorporate what SciNeuro describes as its proprietary blood-brain barrier shuttle technology, designed to help drugs cross the protective barrier around the brain, and which [...]
L-Nutra has raised US$36.5m in series D funding for what it describes as science-driven nutrition for longevity and nutrition as medicine. The round brings its series D total to US$83.5m, the company said. As part of the investment, Mubadala and L-Nutra will establish a local joint venture in Abu Dhabi to produce scientific medical nutrition [...]
Shingles vaccination may slow biological ageing in older adults, research suggests. The study examined more than 3,800 people aged 70 and older and found that those who received the vaccine showed slower biological ageing on average than unvaccinated individuals. The study used data from a nationally representative US survey to assess how shingles vaccination related [...]
Thousands of men in England will get the prostate cancer drug abiraterone on the NHS within weeks. For the first time, patients in England whose cancer has not spread will be able to receive abiraterone as the health service widens access to the treatment. Around 2,000 men diagnosed in the last three months whose cancer [...]
Sharp rises in blood sugar after meals may raise Alzheimer’s risk, according to genetic analysis of more than 350,000 adults. The findings point to after-meal glucose, rather than overall blood sugar, as a possible factor in long-term brain health. Researchers examined genetic and health data from over 350,000 UK Biobank participants aged 40 to 69, [...]
A recent international study that pooled brain scans and memory tests from thousands of adults has shed new light on how structural brain changes are tied to memory decline as people age. The findings show that the connection between shrinking brain tissue and declining memory is nonlinear, stronger in older adults, and not solely driven [...]
