Drug development
Alzheimer’s drug pioneer Anavex is pressing ahead with plans to secure approval for its ground-breaking treatment despite a recent setback. Earlier this year it lodged an appeal against the European Medicines Agency (EMA) decision to reject its application for drug approval in December 2025. But, Anavex has now withdrawn this appeal as it seeks to [...]
So-called 'gamechanger' Alzheimer’s drugs made little noticeable difference for patients in trials, according to a review of anti-amyloid drugs. The analysis looked at trials involving people with mild cognitive impairment or mild dementia. It found the effects of anti-amyloid drugs on cognition and dementia severity over 18 months were “trivial”, while gains in functional ability [...]
A pancreatic cancer drug could double survival rates and cut the risk of death by more than a third, a trial suggests. Pancreatic cancer survival rates are among the lowest of all cancers, with only about 10 per cent of patients in Britain living longer than a year after diagnosis. Researchers at Northwestern University in [...]
An Alzheimer's pill was linked to slower brain shrinkage and improved cognition over nearly three years in early disease, a new analysis suggests. The benefits seen in people with early Alzheimer's disease after a year of treatment with blarcamesine were sustained over nearly three years, according to new analysis from Anavex Life Sciences. Patients treated [...]
Osteoporosis drugs may lower dementia risk, with a study suggesting one widely used treatment could help prevent Alzheimer’s and related dementias. The research found that nitrogen-containing bisphosphonates, drugs widely used to treat osteoporosis, may significantly reduce the risk of Alzheimer’s disease and related dementias in older adults with osteoporosis or fragility fractures. Osteoporosis and dementia [...]
NewLimit has secured an extra US$45m on a US$1.62bn valuation to advance epigenetic reprogramming medicines and prepare for a first clinical study in the coming years. The company is developing therapies to restore youthful function in older cells. Epigenetic reprogramming aims to reset chemical “tags” on DNA and its packaging proteins, restoring healthier gene activity [...]
Researchers have discovered how to block cells dying, in a finding that could lead to new treatments for neurodegenerative conditions like Parkinson’s and Alzheimer’s. The team have identified a small molecule that can selectively block cell death. The findings lay the groundwork for next-generation neuroprotective drugs for degenerative conditions, which currently have no cure or [...]
A new study found that a gene recently recognised as a biomarker for Alzheimer’s disease is actually a cause of it, due to its previously unknown secondary function - and have used artificial intelligence to help unravel this mystery of Alzheimer’s disease and discover a potential treatment that obstructs the gene’s moonlighting role. About one [...]
