Wellness
Thousands of men in England to be offered life-extending prostate cancer drug
Thousands of men in England will get the prostate cancer drug abiraterone on the NHS within weeks.
For the first time, patients in England whose cancer has not spread will be able to receive abiraterone as the health service widens access to the treatment.
Around 2,000 men diagnosed in the last three months whose cancer has not spread will get access to the treatment if it is of clinical benefit.
An additional 7,000 men are expected to be diagnosed each year and will be eligible for the drug.
The national clinical director for cancer at NHS England, professor Peter Johnson, said: “For thousands of men with prostate cancer, this treatment option could be life-changing by helping keep their cancer at bay for several years.
“The life-extending treatment available on the NHS within weeks will mean thousands of men can kick-start their year with the news that they will have a better chance of living longer and healthier lives.
“The NHS will continue to work hard to offer people the most effective and evidence-based treatments, with several new prostate cancer drugs rolled over the last five years.”
Abiraterone is a hormone-blocking tablet that helps stop prostate cancer spreading by cutting off the testosterone it needs to grow.
Research has shown that for these earlier-stage patients, survival after six years is improved, with trials showing 86 per cent of men alive after six years on abiraterone compared with 77 per cent on standard treatment (hormone therapy with or without radiotherapy).
NHS England has been able to expand access to the drug for thousands more eligible patients by securing better-value supply, following clinical advice to roll this out last year.
The NHS has set a target to save over £1bn on clinically effective biosimilar drugs during this parliament. Biosimilars are approved, lower-cost versions of biological medicines.
More than eight in 10 drugs the NHS now prescribes are lower-cost biosimilar or generic medicines, creating funding for other treatments.
The NHS in England already commissions abiraterone, now available as a lower-cost generic medicine, for advanced prostate cancer, having introduced a policy to commission the treatment in December 2024, nearly one year ahead of positive NICE guidance recommending it in November 2025.
NHS England has worked with campaigners including Prostate Cancer UK to secure this rollout.
In the past five years alone, the NHS in England has also commissioned targeted prostate cancer therapies, including the branded drugs enzalutamide, darolutamide, relugolix and apalutamide.
The health and social care secretary, Wes Streeting, said: “When you’re living with prostate cancer, every day with your loved ones matters.
“I’m delighted the NHS have taken the steps needed to make the drug available, giving thousands of men access to abiraterone, a treatment that significantly improves survival rates and can give patients precious extra years of life.
“We’re backing the best clinical evidence, making smart funding decisions, and ensuring patients get the care they need when they need it most.
“We’re serious about improving prostate cancer outcomes, treating it faster and giving loved ones more time together.”
In parallel with confirming abiraterone’s commissioning, NHS England will also offer blood plasma treatment for people with the rare condition Clarkson’s Syndrome, and genetic testing for parents with pre-existing conditions going through IVF, following clinical advice and enabled by long-term funding.
Shingles vaccination may slow biological ageing in older adults, research suggests.
The study examined more than 3,800 people aged 70 and older and found that those who received the vaccine showed slower biological ageing on average than unvaccinated individuals.
The study used data from a nationally representative US survey to assess how shingles vaccination related to several measures of biological ageing.
Even when controlling for other sociodemographic and health variables, vaccinated individuals had lower inflammation measurements, slower epigenetic ageing (changes in how genes are switched on or off) and slower transcriptomic ageing (changes in how genes are transcribed into RNA used to create proteins).
The research was carried out at the USC Leonard Davis School of Gerontology, using data from the US Health and Retirement Study.
Shingles, also called herpes zoster, is a painful, blistering skin rash caused by reactivation of the chickenpox virus. Anyone who has had chickenpox is at risk of shingles. While shingles can occur at younger ages, risk is higher for those 50 and older and for immunocompromised people. Vaccination offers protection from shingles and lowers the chance of postherpetic neuralgia, or long-term pain after infection.
While vaccines are designed to protect against acute infection, recent research has highlighted a possible link between adult vaccines, including those for shingles and influenza, and lower risks of dementia and other neurodegenerative disorders, said research associate professor of gerontology Jung Ki Kim, the study’s first author.
“This study adds to emerging evidence that vaccines could play a role in promoting healthy ageing by modulating biological systems beyond infection prevention.”
Biological ageing refers to how the body changes over time, including how well organs and systems are working, unlike chronological ageing, which is simply time passing. Two people who are both 65 years old may look very different inside: one may have the biological profile of someone younger, while another may show signs of ageing earlier.
Kim and coauthor Eileen Crimmins, USC university professor and AARP professor of gerontology, measured seven aspects of biological ageing: inflammation, innate immunity (the body’s general defences against infection), adaptive immunity (responses to specific pathogens after exposure or vaccination), cardiovascular haemodynamics (blood flow), neurodegeneration, epigenetic ageing and transcriptomic ageing. The team also used the measures collectively to record a composite biological ageing score.
Chronic, low-level inflammation is a contributor to many age-related conditions, including heart disease, frailty and cognitive decline. This phenomenon is known as inflammaging, Kim said.
“By helping to reduce this background inflammation, possibly by preventing reactivation of the virus that causes shingles, the vaccine may play a role in supporting healthier ageing. While the exact biological mechanisms remain to be understood, the potential for vaccination to reduce inflammation makes it a promising addition to broader strategies aimed at promoting resilience and slowing age-related decline.”
The effect may persist. When analysing how time since vaccination related to results, Kim and Crimmins found that participants who received their vaccine four or more years before providing their blood sample still showed slower epigenetic, transcriptomic and overall biological ageing on average than unvaccinated participants.
“These findings indicate that shingles vaccination influences key domains linked to the ageing process. While further research is needed to replicate and extend these findings, especially using longitudinal and experimental designs, our study adds to a growing body of work suggesting that vaccines may play a role in healthy ageing strategies beyond solely preventing acute illness.
The work was supported by the National Institute on Aging at the National Institutes of Health. The Health and Retirement Study is supported by the National Institute on Aging.
Veteran male athletes may face higher heart risk during exercise if they have existing heart scarring, new research suggests.
The study found that male endurance athletes aged over 50 were more likely to experience abnormal heart rhythms during training if scarring was present.
Nine in 10 sudden cardiac deaths during sport occur in older male athletes.
Researchers at the University of Leeds tracked 106 healthy male endurance athletes aged over 50 who had been doing more than 10 hours of running or cycling weekly for at least 15 years.
They matched training data from wearables with implantable loop recorders to align heart rhythms with activity.
Over two years, about one in four participants experienced ventricular tachycardia, a fast, abnormal rhythm arising from the heart’s lower chambers, during or just after exercising.
Three quarters of those who had these episodes had heart scarring. There were three sustained episodes during exercise, all in athletes with scarring.
Scarring may be caused by heart attacks, disease or cumulative exertion from years of high-intensity exercise.
Dr Wasim Javed, research fellow at the University of Leeds and lead author, said: “Our study shows that exercise was only associated with a risk of developing abnormal heart rhythms in those who were already high risk due to heart scarring.
“Athletes who developed abnormal heart rhythms were not exercising more or harder than athletes without abnormal heart rhythms.
“This suggests that exercise itself is not the cause, but could act as a trigger for dangerous heart rhythms in those athletes already with an underlying heart issue.”
“Exercise is safe and has immense benefits – but athletes in this group should have regular health checks to make sure they stay healthy.”
The researchers said their findings support the use of wearable technology for athletes who want to monitor their heart rate for unusual activity.
Childhood exposure to indoor air pollution may have long-term effects on brain health, with cognitive impairment appearing decades later, new research suggests.
The study analysed data from over 7,000 Chinese adults aged 45 and above using machine learning techniques.
Nearly 30 per cent of the global population, roughly 2.4bn people, still cook without clean fuels such as gas or electricity, instead using solid fuels like coal, wood and plant waste.
Researchers at the University of Helsinki found that individuals exposed as children to indoor air pollution from solid fuels performed significantly worse on cognitive tests in adulthood, particularly in episodic memory and overall mental health.
The study identified two main pathways through which childhood exposure may contribute to poorer cognitive performance: biological, including being overweight and limitations in daily activities; and socioeconomic, with exposure associated with lower education and income levels.
Men, smokers and regular alcohol users were particularly vulnerable to the detrimental effects.
Xu Zong, the study’s author, said: “Our study emphasises that early exposure to air pollution affects later cognitive health through both biological and social pathways.
“That is why public health efforts should combine clean energy initiatives with preventive strategies that support lifelong health and positive behaviours.
“Switching to cleaner fuels, such as gas or electricity, is not merely an environmental or respiratory health measure.
“It is also an investment in long-term cognitive wellbeing that could safeguard brain health for future generations.”
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