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Imaging facilities share $3 million Alzheimer’s research grant

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Imaging facilities share $3 million Alzheimer’s research grant

The Biomedical Imaging Center at the Beckman Institute for Advanced Science and Technology has received $3 million in funding that will help develop diagnostic tools and imaging agents for the early detection of Alzheimer’s disease.

The grant is one of the first federal grants to bridge Beckman’s Magnetic Resonance Imaging Laboratory and Molecular Imaging Laboratory, which are both part of Beckman’s Biomedical Imaging Center.

A team led by Liviu M. Mirica, Wawryzneic “Wawosz” Dobrucki and Dr Daniel A. Llano received the grant from the U.S. National Institute on Aging of the National Institutes of Health to develop and test multi-modal imaging agents for the detection of Alzheimer’s disease and related dementias.

“I’m really excited about the opportunity to collaborate with different scientists from different fields,” said Mirica, a synthetic chemist and the William H. and Janet G. Lycan Professor of Chemistry in the School of Chemical Sciences at the University of Illinois Urbana-Champaign. His research group specializes in building and characterizing synthetic inorganic molecules in vitro: outside of the body.

“I’m looking forward to high-resolution imaging of the brain and its structures,” Dobrucki said, who is the Neil and Carol Ruzic Scholar for Biomedical and Translational Sciences, is an imaging expert who works extensively with PET scanning in Beckman’s Molecular Imaging Laboratory.

Llano, a professor of molecular and integrated physiology and a physician-surgeon, is a practicing neurologist who sees patients daily and specializes in in vivo brain studies: those inside the body.

“The potential impact that this project will have on Alzheimer’s is what I’m most excited about,” Llano said.

Understanding Alzheimer’s disease

Alzheimer’s disease is a neurodegenerative disease that negatively affects brain function and cognitive abilities. Along with Parkinson’s disease, amyotrophic lateral sclerosis, and other disorders, Alzheimer’s falls under the category of amyloid diseases. Amyloids are small groups of abnormally fibrous or misfolded proteins that do not commonly serve a purpose in the body.

A key marker of Alzheimer’s disease is the presence of amyloid plaques: large buildups of smaller beta-amyloid peptide aggregates. Peptides are short chains of amino acids that eventually create proteins. Neuroinflammation and oxidative stress in the brain are also major markers of Alzheimer’s.

The detection and treatment of neurodegenerative diseases is especially difficult because of the blood-brain barrier, a semipermeable system of blood vessels and capillaries that controls the flow of ions, molecules, and cells between the blood and the brain.

To be effective, imaging agents and drug therapies, which are made of molecules or antibodies, need to be able to pass through.

Diagnosis and treatment

Diagnosing Alzheimer’s disease with a high degree of accuracy requires identifying the amyloid aggregates and can only be completed during post-mortem investigation. This creates a need for diagnostic tools that can quickly locate soluble beta-amyloid peptide aggregates and larger amyloid plaques in a living patient.

PET and MRI are two noninvasive imaging methods commonly used in clinical settings, however, no MRI contrast agents that target amyloid aggregates have been developed.

The few FDA-approved PET imaging agents are insufficient at detecting small-scale amyloid abnormalities or in some cases, lead to false-positives test results when diagnosing Alzheimer’s.

Mirica emphasised the importance of developing diagnostic tools to target smaller beta-amyloid peptides and other signs of neuroinflammation and oxidative stress for a variety of reasons.

Creating multi-modal tools that can be used for both PET and MRI scans will give researchers a better idea of who is at risk for developing Alzheimer’s, who truly has the disease, and at what stage.

The $3M plan

Mirica, Dobrucki, and Llano will receive the $3 million grant over the course of five years to generate novel dual-purpose imaging agents that can easily pass the blood-brain barrier and are compatible with both PET and MRI scanners.

This will enable the detection of neurodegenerative diseases at earlier stages and “will help tremendously in developing better therapies,” Mirica said.

Brad Sutton, a professor of bioengineering and the technical director of Beckman’s Biomedical Imaging Center, will assist the team by performing in vivo MRI studies. They will then evaluate the imaging agent’s ability as a dual modality diagnostic agent for Alzheimer’s disease and related dementias.

Already, Mirica and his collaborators have developed a series of customised molecules that can cross the blood-brain barrier and help detect both smaller soluble beta-amyloid peptides and larger insoluble amyloids.

They have also developed a copper-based PET imaging agent that led to the successful imaging of amyloid plaques in transgenic Alzheimer’s mice.

Looking ahead, the team believes that these agents can be developed to pass through the blood-brain barrier in humans and image multiple markers of Alzheimer’s disease and other neurodegenerative diseases at earlier stages.

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Agetech investment & innovation round-up

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Two London boroughs have launched their own initiatives aimed at supporting their ageing resident populations. 

Long-term gut health and female finance, London likes longevity

New York innovator Salvo Health has secured $8.5m in Series A round as it looks to develop new, long-term, gut-health treatments.

The funding round was led by ManchesterStory, City Light Capital and Threshold Ventures, with additional support from The Artemis Fund, Owl Capital, Impact X Capital Partners, Torch Capital and Felicis Ventures. 

Eric Collins, co-founder and general partner of Impact X Capital Partners, a UK-based venture capital firm, said: “The key with Salvo is patient-centred care.

“It’s critical to expand access to food as medicine and behavioural health to improve outcomes and lower, long-term health care costs.

“Salvo does exactly that and has shown 76 per cent of patients report improved symptoms, with five accepted abstracts on outcomes, and a 79 per cent drop in GI-related ER utilisation for its patients.

“We can have better care at lower costs with innovation, in the US, and ultimately in the UK and Europe as well.”

The raise brings Salvo’s total equity funding to US$21.6m. Roughly 60m Americans experience chronic gastrointestinal conditions each year.

Salvo Health is positioning itself in the space between overburdened clinics and patients’ everyday lives.

Female longevity in focus

Xella Health – a women’s precision platform focused on fertility, ageing, and body changes – has raised over US$3.7m in pre-seed funding.

The funds will support product finalisation, partnerships, and a Spring 2026 launch, focused on sex-specific longevity and preventive care.

The round was led by Precursor Ventures, with participation from Capital F, Ulu Ventures, and other funds, as well as, strategic angel investors across healthcare, diagnostics, and consumer technology.

Xella is aiming to propel women’s health beyond symptom-based care and fragmented testing to deliver ‘integrated biological insight, clarity, and foresight’. 

The company combines advanced diagnostics, longitudinal data, and personalised clinician-led guidance to help women understand what’s happening in their bodies today – and what lies ahead – across fertility, chronic conditions, hormonal health, early cancer detection, and preventative care.

“Our mission is to give women the answers and care they have always deserved,” said Kelly Lacob, co-founder & CEO of Xella.

“Xella is building the infrastructure to decode female biology – getting to the root cause of conditions that uniquely, differently or disproportionately affect women, many of which suffer from an unacceptably poor standard of care today.”

“Xella is rethinking women’s health from the ground up – starting with the insight women need to make sense of their own biology over time,” said Ashtan Jordan, principal at Precursor Ventures. 

Age well in London

Two London boroughs have launched their own initiatives aimed at supporting their ageing resident populations. 

Basildon Council has approved a new Ageing Population Strategy to support older residents live healthy, independent and connected lives.

The number of residents aged 65 and over in Basildon is projected to rise steadily over the next decade, reflecting national longevity trends.

The council says its ‘taking a proactive, preventative approach to ensure Basildon remains an inclusive, accessible and sustainable place for residents of all ages’.

The strategy emphasises strong partnership working with health services, voluntary and community organisations, local businesses and residents.

Key commitments include:

  •       Supporting people to remain independent in their own homes for longer,
  •       Promoting age-friendly design in town centres and public spaces,
  •       Strengthening dementia-friendly communities,
  •       Expanding opportunities for volunteering and employment, and
  •       Continuing investment in activity centres and community-led initiatives that reduce loneliness.

Cllr Melissa McGeorge, cabinet member for ageing population & health, said: “Our ambition is clear: to make Basildon a place where people can age well, feel valued, and continue to thrive at every stage of later life.

The ‘Life Curve’

Meanwhile the London Borough of Richmond has launched a new self-assessment tool developed by ADL Research and Newcastle University to help boost longevity.

The ‘Life Curve’ tool is designed to support healthy ageing with personalised advice and practical steps on how to stay active and independent.

Councillor Allen, lead member for adult social care, said: “Getting older doesn’t have to mean we stop being independent and there are small steps we can take to help reduce how getting older limits our lives.

“We have tools and services available in the borough to support residents to take these small daily steps to maintain their health and reduce the risk of conditions like heart disease, cancer and dementia. 

“A new tool accessible right from your phone or any other online device is ‘Independent Richmond’, which helps you understand where you are on The Life Curve to help stay on track with healthy habits, keeping active and stay independent for longer.” 

 

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Bryan Johnson launches US$1m longevity programme

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Bryan Johnson has launched a US$1m-a-year longevity programme with just three places, offering access to the exact protocol he has followed for five years.

The programme, called “Immortals”, is offered by the former fintech entrepreneur, now a prominent and often controversial figure in longevity.

Johnson’s unconventional methods have included Botox injections in his genitals (Botox relaxes muscles) and transfusions of blood from his teenage son.

There is no evidence these will help him outlive others.

The “Immortals” package includes a dedicated concierge team, 24/7 access to the BryanAI health coach, extensive testing, continuous tracking of millions of biological data points and what Johnson calls the “best skin and hair protocols.

A lower-cost supported tier is available at US$60,000 per year.

Rivals also target the ultra-wealthy: Biograph’s premium membership costs US$15,000 per year, while Fountain Life’s “ultimate longevity programme” is priced at US$21,500 annually.

Despite the higher price, Johnson’s offer is built on exclusivity, with only three spots available.

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Cognition and Cera expand Alzheimer’s clinical trials access

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Cognition Health and Cera have partnered to expand access to Alzheimer’s clinical trials across the UK.

The collaboration links Re:Cognition Health’s specialist brain health clinics and trial expertise with Cera’s 2.5 million monthly home care visits, creating new pathways to identify and support people earlier in their health journey.

By connecting home care with specialist research centres, the partners aim to offer more people the chance to join studies, giving access to advanced assessment and emerging treatments while contributing to future therapies.

Dr Ben Maruthappu MBE, chief executive and founder of Cera, said: “Many older adults are currently ‘invisible’ to the clinical trials research system because they cannot access traditional clinic-centric recruitment.

“By enabling responsible, consented identification and screening within the home, we can bridge the gap between the community and the clinic.

“We are offering the older generation a seat at the table of global drug discovery, ensuring that the path to a cure starts where they are most comfortable—in their own daily lives.”

Re:Cognition Health has contributed to the development of lecanemab (Leqembi) and donanemab (Kisunla) through international trials, introducing disease-modifying approaches that are reshaping early intervention in Alzheimer’s care.

Older adults remain under-represented in research. NIHR data indicate only about 15 per cent of trial participants are 75 or older, despite high multimorbidity in this group. Dementia trial recruitment in the UK also lags other disease areas.

Through this collaboration, individuals who have not yet accessed specialist memory services can be referred earlier for assessment and potential study participation, with access to new-generation therapies where appropriate.

Cera’s technology-enabled home healthcare model, with daily patient contact and consented data capture, allows timely referral of potential participants from familiar settings to Re:Cognition Health clinics.

Together, the organisations will support earlier and more equitable participation by leveraging Cera’s scale and real-time insights. Carers and nurses deliver visits roughly every second on average, enabling early identification of those who may benefit from memory assessment.

Dr Emer MacSweeney, chief executive and founder of Re:Cognition Health, said: “With one in three people expected to develop dementia in their lifetime, it is essential that we create more inclusive and accessible routes into research.

“This collaboration enables us to extend our reach beyond traditional clinic settings and ensure that people who may benefit from early assessment and research participation are supported to do so.

“Clinical trials offer individuals access to the most advanced diagnostics and emerging treatments, alongside expert medical oversight.

“By identifying people earlier and guiding them through every stage of their journey, we can help improve participants’ experience and potential outcomes, while accelerating the development of the next generation of Alzheimer’s therapies.”

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