News
High blood pressure in 30s linked to later life dementia risk

Treating high blood pressure in young and middle-aged adults could help prevent later life dementia and Alzheimer’s, a new study suggests.
Research published by UC Davis in JAMA Network Open, a monthly open access medical journal produced by the American Medical Association, reveals that hypertension in your 30s is associated with worse brain health around the age of 75, especially in men.
By comparing brain magnetic resonance imaging (MRI) scans of older adults who either did or didn’t have hypertension between the ages of 30 and 40, the researchers found that the high blood pressure group had significantly lower regional brain volumes and worse white matter integrity, both factors linked with dementia.
Some changes, such as decreased grey matter volume and frontal cortex mass, were more apparent in men than women, which the researchers said could be connected to the protective benefits of oestrogen in females before the onset of the menopause.
Other recent studies have also made the connection between hypertension and brain health, including one published last month in the Euroepean Heart Journal.
This latest research reinforces how vital it is that blood pressure is properly managed to avoid any negative impact in later life.
Kristen M George, an assistant professor in the Department of Public Health Sciences at UC Davis in California and first author of the report, said: “Treatment for dementia is extremely limited, so identifying modifiable risk and protective factors over the life course is key to reducing disease burden.

First author of the report, Kristen M. George. Credit UC Davis Health
“High blood pressure is an incredibly common and treatable risk factor associated with dementia. This study indicates hypertension status in early adulthood is important for brain health decades later.”
High blood pressure is cited by the NHS as a sustained reading of more than 140/90 mmHG or above, Anything less than 130/80 mmHG is considered normal.
An estimated 1.3 billion people are affected by hypertension globally and the condition – regarded as the second biggest risk factor for disease after poor diet – kills around 10 million annually, according to figures from the World Heart Federation.
Left untreated it can not only cause heart failure, coronary artery disease and stroke but increase the risk of chronic kidney disease, peripheral arterial disease and vascular dementia.
The UC Davis study noted that the rate of high blood pressure varies by sex and race, with about 50% of men suffering from hypertension compared to 44% of women. The rate of hypertension is about 56% in the adult Black population, 48% in the white community, and 46% and 39% respectively amongst Asian and Hispanic peoples.
African-Americans aged 35-64 are 50% more likely to have high blood pressure than whites.
The researchers looked at data from 427 participants from the Kaiser Healthy Aging and Diverse Life Experiences (KHANDLE) study and the Study of Healthy Aging in African Americans (STAR) spanning 21 years between 1964 and 1985, which provided them with a diverse group of older Asian, Black, Latino and white adults.
They obtained two blood pressure readings from when the participants were between the ages of 30 and 40. This allowed them to determine if they had been hypertensive, were transitioning to elevated blood pressure or had normal BP in young adulthood.
MRI scans of the participants conducted between 2017 and 2022 allowed them to look for late-life neuroimaging biomarkers of neurodegeneration and white matter integrity.
A significant reduction in cerebral gray matter volume was seen in both men and women with hypertension. But it was stronger in males.
Compared to participants with normal blood pressure, the brain scans of those moving to raised BP or with hypertension, showed lower cerebral gray matter volume, frontal cortex volume and fractional anisotropy (a measure of brain connectivity).
The scores for men with high blood pressure were lower than those for women.
The researchers noted that due to the sample size, they could not examine racial and ethnic disparity and recommended interpreting results regarding sex differences with caution.
They also noted that the MRI data was only available from one time-point late in life which could only determine physical properties, like volumetric differences, not specific evidence of neurodegeneration over time.
But Rachel Whitmer, senior author of the study and a professor in the departments of Public Health Sciences and Neurology and chief of the Division of Epidemiology, as well as the associate director of the UC Davis Alzheimer’s Center, said: “This study truly demonstrates the importance of early life risk factors, and that to age well, you need to take care of yourself throughout life – heart health is brain health.
“We are excited to be able to continue following these participants and to uncover more about what one can do in early life to set yourself up for healthy brain ageing in late life.”
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Wellness
Study reveals link between cheese and dementia

A 25-year Swedish study links higher cheese intake to lower Alzheimer’s risk in people without known genetic risk, with cream also tied to lower dementia risk.
However, researchers emphasise that the results should be interpreted with caution.
The study tracked 27,670 people over 25 years.
During that time, 3,208 participants were diagnosed with dementia.
Among individuals without a known genetic risk for Alzheimer’s disease, those who consumed more than 50 grams of full-fat cheese per day showed a 13 to 17 per cent lower risk of developing Alzheimer’s.
This association did not appear in participants who carried genetic risk factors for the disease.
People who consumed more than 20 grams of full-fat cream per day also showed a lower risk of dementia overall, ranging from 16 to 24 per cent.
No meaningful links were found for low-fat or high-fat milk, fermented or non-fermented milk, or low-fat cream.
The results stand out because public health guidance has long encouraged people to choose low-fat dairy to protect heart health.
This connection matters because cardiovascular disease (conditions affecting the heart and blood vessels) and dementia share many underlying risk factors, including high blood pressure, diabetes and obesity.
When evidence from previous studies is combined, analyses suggest that cheese consumption may also be linked to a lower risk of heart disease, and that full-fat dairy does not necessarily increase cardiovascular risk.
Several other studies have explored whether similar patterns apply to brain health, but the results are mixed.
Evidence overall suggests that studies conducted in Asian populations are more likely to report benefits of dairy consumption for cognitive health (the ability to think, remember and reason), while many European studies do not.
One possible explanation is that average dairy intake tends to be much lower in Asian countries, meaning modest consumption may have different effects than higher intakes.
For example, one Japanese study reported a reduced dementia risk among people who ate cheese, but overall consumption levels were very low and the research was sponsored by a cheese producer.
In contrast, another Japanese study funded by government grants found no protective effect of cheese.
Some long-term European studies have also reported benefits.
In a Finnish study of 2,497 middle-aged men followed for 22 years, cheese was the only food associated with a lower dementia risk, reduced by 28 per cent.
Other dietary factors also appear to matter.
Higher consumption of milk and processed red meat was associated with worse performance on cognitive tests, while fish intake was linked to better results.
A large study in the UK that followed nearly 250,000 people found lower dementia risk among those who ate fish two to four times a week, fruit daily and cheese once a week.
However, these studies have important limitations.
What people eat is usually self-reported, and changes in memory can affect both eating habits and how accurately people remember what they have eaten. To deal with this, the Swedish researchers took two extra steps.
First, they excluded anyone who already had dementia when the study began.
Then they repeated the same calculations after removing people who went on to develop dementia within the first ten years of the study.
This did not mean starting the study again or recruiting new participants. It simply meant re-checking the results using a smaller group of people who remained dementia-free for longer.
The reason for doing this is that the early stages of dementia can subtly change behaviour long before diagnosis.
People may eat differently, lose appetite or struggle to recall their usual diet. By focusing on participants who stayed cognitively healthy for many years, the researchers reduced the chance that these early changes were influencing the results.
Another important question is whether substitution played a role.
Some of the apparent benefits may reflect replacing red or processed meat with cheese or cream, rather than an effect of dairy itself.
Supporting this idea, the Swedish study found no association between full-fat dairy and dementia risk among participants whose diets remained stable over five years.
Most importantly, foods should not be considered in isolation.
Dietary patterns matter more than individual ingredients. Diets such as the Mediterranean diet, which is consistently associated with lower risks of both dementia and heart disease, include cheese alongside vegetables, fish, whole grains and fruit.
In the Swedish study, people who consumed more full-fat cheese and cream were also more educated, less likely to be overweight and had lower rates of conditions linked to dementia, including heart disease, stroke, high blood pressure and diabetes.
All of these factors independently reduce dementia risk.
This suggests that higher cheese intake tended to occur within healthier overall lifestyles, rather than alongside excess calorie consumption or poor metabolic health.
Overall, the evidence does not support the idea that full-fat dairy causes dementia, nor that fermented milk products reliably protect against it.
Full-fat cheese contains several nutrients relevant to brain health, including fat-soluble vitamins A, D and K2, as well as vitamin B12, folate, iodine, zinc and selenium.
These nutrients play roles in neurological function and may help support cognitive health.
That said, the data do not justify eating large amounts of cheese or cream as protective foods against dementia or heart disease.
The most consistent message remains that balanced diets, moderation and overall lifestyle matter far more than any single item on the cheese board.
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